ArticleMayo Clinic proceedings2012
Meningitis with a negative cerebrospinal fluid Gram stain in adults: risk classification for an adverse clinical outcome.
Article in Mayo Clinic proceedings, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Article
- Diagnostic comparison of microbial culture and polymerase chain reaction for the diagnosis of bacterial meningitis in a tertiary hospital, North West Ethiopia.IJID regions · 2025Article
- Advancements in Cerebrospinal Fluid Biosensors: Bridging the Gap from Early Diagnosis to the Detection of Rare Diseases.Sensors (Basel, Switzerland) · 2024Review
- Article
- The diagnostic utility of the "Thwaites' system" and "lancet consensus scoring system" in tuberculous vs. non-tuberculous subacute and chronic meningitis: multicenter analysis of 395 adult patients.BMC infectious diseases · 2020Article
- Compliance with international guidelines in adults with encephalitis.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2020Article
- Isolation and identification ofAccess microbiology · 2020Article
- Economic analysis of rapid multiplex polymerase chain reaction testing for meningitis/encephalitis in adult patients.Infection · 2019Article
- Risk Factors of External Ventricular Drainage-Related Infections: A Retrospective Study of 147 Pediatric Post-tumor Resection Patients in a Single Center.Frontiers in neurology · 2019Article
- Community-Acquired Meningitis in HIV-Infected Patients in the United States.AIDS patient care and STDs · 2018Article
- Pleocytosis is not fully responsible for low CSF glucose in meningitis.Neurology(R) neuroimmunology & neuroinflammation · 2018Article
- Aseptic meningitis in adults and children: Diagnostic and management challenges.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2017Article
- Cranial Imaging Before Lumbar Puncture in Adults With Community-Acquired Meningitis: Clinical Utility and Adherence to the Infectious Diseases Society of America Guidelines.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Article
- Listeria monocytogenes in Fresh Produce: Outbreaks, Prevalence and Contamination Levels.Foods (Basel, Switzerland) · 2017Article
- Epidemiology of meningitis with a negative CSF Gram stain: under-utilization of available diagnostic tests.Epidemiology and infection · 2016Observational
- Hypoglycorrhachia in adults with community-acquired meningitis: etiologies and prognostic significance.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2015Article
- Burden of bacterial meningitis: a retrospective review on laboratory parameters and factors associated with death in meningitis, kelantan malaysia.Nagoya journal of medical science · 2015Article
- Community-acquired meningitis in older adults: clinical features, etiology, and prognostic factors.Journal of the American Geriatrics Society · 2014Article
- The differential diagnosis of hypoglycorrhachia in adult patients.The American journal of the medical sciences · 2014Article
Corrections and comments
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5 authors.
Funding
Abstract
objectiveTo derive and validate a risk score for an adverse clinical outcome in adults with meningitis and a negative cerebrospinal fluid (CSF) Gram stain. PATIENTS AND
methodsWe conducted a retrospective study of 567 adults from Houston, Texas, with meningitis evaluated between January 1, 2005, and January 1, 2010. The patients were divided into derivation (N=292) and validation (N=275) cohorts. An adverse clinical outcome was defined as a Glasgow Outcome Scale score of 4 or less.
resultsOf the 567 patients, 62 (11%) had an adverse clinical outcome. A predictive model was created using 3 baseline variables that were independently associated with an adverse clinical outcome (P<.05): age greater than 60 years, abnormal findings on neurologic examination (altered mental status, focal neurologic deficits, or seizures), and CSF glucose level of less than 2.4975 mmol/L (to convert CSF glucose to mmol/L, multiply by 0.05551). The model classified patients into 2 categories of risk for an adverse clinical outcome--derivation sample: low risk, 0.6% and high risk, 32.8%; P<.001; and validation sample: low risk, 0.5% and high risk, 21.1%; P<.001.
conclusionAdults with meningitis and a negative CSF Gram stain can be accurately stratified for the risk of an adverse clinical outcome using clinical variables available at presentation.
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