ArticleNeuron2012
The spatial pattern of cochlear amplification.
Article in Neuron, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 91 citations in OpenAlex.
- Broadband amplification of organ of Corti vibrations in the mouse cochlear apex.bioRxiv : the preprint server for biology · 2026Article
- An artificial cilia-based array system for sound frequency decoding and resonance-responsive drug release.Nature biomedical engineering · 2026Article
- Gene supplementation with precise transgene expression rescues hearing loss in a mouse model with an Mpzl2 East Asian founder variant.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Amplification through local critical behavior in the mammalian cochlea.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- SIRT3 regulates PFKFB3-mediated glycolysis to attenuate cisplatin-induced ototoxicity both in vivo and in vitro.Archives of toxicology · 2025Article
- Outer hair cells stir cochlear fluids.eLife · 2025Article
- Corti Fluid Is a Medium for Outer Hair Cell Force Transmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Outer hair cells stir cochlear fluids.bioRxiv : the preprint server for biology · 2024Article
- The Critical Thing about the Ear's Sensory Hair Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Rate-dependent cochlear outer hair cell force generation: Models and parameter estimation.Biophysical journal · 2024Article
- The Origin Along the Cochlea of Otoacoustic Emissions Evoked by Mid-Frequency Tone Pips.Journal of the Association for Research in Otolaryngology : JARO · 2024Article
- Article
- SLC26 Anion Transporters.Handbook of experimental pharmacology · 2024Review
- The spatial buildup of nonlinear compression in the cochlea.Frontiers in cellular neuroscience · 2024Article
- Elevator-like movements of prestin mediate outer hair cell electromotility.Nature communications · 2023Article
- Intracochlear overdrive: Characterizing nonlinear wave amplification in the mouse apex.The Journal of the Acoustical Society of America · 2023Article
- Cochlear Amplification in the Short-Wave Region by Outer Hair Cells changing Organ-of-Corti area to Amplify the Fluid Traveling Wave.Hearing research · 2022Article
- The impact of targeted ablation of one row of outer hair cells and Deiters' cells on cochlear amplification.Journal of neurophysiology · 2022Article
- Salicylate-induced changes in organ of Corti vibrations.Hearing research · 2022Article
- An outer hair cell-powered global hydromechanical mechanism for cochlear amplification.Hearing research · 2022Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Sensorineural hearing loss, which stems primarily from the failure of mechanosensory hair cells, changes the traveling waves that transmit acoustic signals along the cochlea. However, the connection between cochlear mechanics and the amplificatory function of hair cells remains unclear. Using an optical technique that permits the targeted inactivation of prestin, a protein of outer hair cells that generates forces on the basilar membrane, we demonstrate that these forces interact locally with cochlear traveling waves to achieve enormous mechanical amplification. By perturbing amplification in narrow segments of the basilar membrane, we further show that a cochlear traveling wave accumulates gain as it approaches its peak. Analysis of these results indicates that cochlear amplification produces negative damping that counters the viscous drag impeding traveling waves; targeted photoinactivation locally interrupts this compensation. These results reveal the locus of amplification in cochlear traveling waves and connect the characteristics of normal hearing to molecular forces.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.