Evidence map›Paper›PMID 23217617›Full record

ReviewVirology2013

Barriers of hepatitis C virus interspecies transmission.

Lisa Sandmann, Alexander Ploss

Abstract readReview
In one paragraph

Review in Virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Experimental models of hepatitis B and C - new insights and progress.Nature reviews. Gastroenterology & hepatology · 2016
    Review
  6. Article
  7. Article
  8. Article
  9. Visualizing hepatitis C virus infection in humanized mice.Journal of immunological methods · 2014
    Review
  10. Review
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Lisa SandmannLaboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller University, New York, NY 10065, USA.
Alexander Ploss

Funding

Modeling human hepatotropic infections in complex tissue organoidsR01DK085713 · NIDDK · ROCKEFELLER UNIVERSITY · PI BHATIA, SANGEETA N., RICE, CHARLES M · 2009 to 2013
$5.6M
Identification and characterization of cellular factors involved in HCV entryR01AI072613 · NIAID · ROCKEFELLER UNIVERSITY · PI RICE, CHARLES M · 2007 to 2016
$4.7M
Simianizing hepatitis C: Defining the species-tropism of a hepatotropic virusR01AI090055 · NIAID · ROCKEFELLER UNIVERSITY · PI RICE, CHARLES M · 2010 to 2014
$2.1M
An inbred mouse model for HCV infection, immunity andpathogenesisRC1DK087193 · NIDDK · ROCKEFELLER UNIVERSITY · PI RICE, CHARLES M · 2009 to 2010
$995k
NIAID NIH HHS R01 AI072613NIAID NIH HHS R01 AI090055NIDDK NIH HHS R01 DK085713NIDDK NIH HHS RC1 DK087193
6 · The paper itself

Abstract

Hepatitis C virus (HCV) is a major causative agent of severe liver disease including fibrosis, cirrhosis and liver cancer. Therapy has improved over the years, but continues to be associated with adverse side effects and variable success rates. Furthermore, a vaccine protecting against HCV infection remains elusive. Development of more effective intervention measures has been delayed by the lack of a suitable animal model. Naturally, HCV infects only humans and chimpanzees. The determinants of this limited host range are poorly understood in part due to difficulties of studying HCV in cell culture. Some progress has been made elucidating the barriers for the HCV lifecycle in non-permissive species which will help in the future to construct animal models for HCV infection, immunity and pathogenesis.

Indexed as

Gene Expression Regulation, ViralAnimalsCell Culture TechniquesDisease Models, AnimalHepacivirusHepatitis C, ChronicHost SpecificityHumansMiceMice, TransgenicPan troglodytesRNA, ViralVirus InternalizationVirus ReplicationRNA, Viral

Identifiers

PMID23217617
PMCPMC3523278

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.