Evidence map›Paper›PMID 23217578›Full record

ArticlePsychiatry research2012

A preliminary examination of how serotonergic polymorphisms influence brain response following an adolescent cannabis intervention.

Sarah W Feldstein Ewing, Hilary K Mead, Uma Yezhuvath, Sam Dewitt, Kent E Hutchison, Francesca M Filbey

Abstract read
In one paragraph

Article in Psychiatry research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. The hyper-sentient addict: an exteroception model of addiction.The American journal of drug and alcohol abuse · 2015
    Pooled it
  3. Trial
  4. Behavioral economic predictors of brief alcohol intervention outcomes.Journal of consulting and clinical psychology · 2015
    Trial
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Functional connectivity and cannabis use in high-risk adolescents.The American journal of drug and alcohol abuse · 2013
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Sarah W Feldstein EwingUniversity of New Mexico Center on Alcohol and Substance Abuse Addictions, 1 University of New Mexico, MSC06 3890, Albuquerque, NM 87131, USA. swfeld@unm.edu
Hilary K Mead
Uma Yezhuvath
Sam Dewitt
Kent E Hutchison
Francesca M Filbey
The University of Texas at Dallas · USSeattle Children's Hospital · USUniversity of Colorado Boulder · USUniversity of New Mexico · US

Funding

Adolescent Response to Psychotherapy: The Role of Neuronal NetworksR03DA027892 · NIDA · THE MIND RESEARCH NETWORK · PI FELDSTEIN EWING, SARAH W. · 2010 to 2010
$245k
NIDA NIH HHS 1R03DA027892-01NIDA NIH HHS R03 DA027892
6 · The paper itself

Abstract

Given the link between depression, anxiety, and cannabis abuse, a serotonin receptor (rs6311) and transporter polymorphism (rs2020936) were examined as moderators of neural response as measured by functional magnetic resonance imaging following a psychosocial treatment for cannabis use disorders (CUDs). While the proposed hypotheses were unsupported, we found that the rs6311 C allele was significantly related to brain activation (medial frontal gyrus, precuneus), indicating the role of this serotonin receptor in adolescent treatment response.

Indexed as

Marijuana AbuseAdolescentBehavioral SymptomsBrainCognitive Behavioral TherapyDNA Mutational AnalysisFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleOxygenPolymorphism, GeneticReceptors, SerotoninSerotonin Plasma Membrane Transport ProteinsOxygenReceptors, SerotoninSerotonin Plasma Membrane Transport Proteins

Identifiers

PMID23217578
PMCPMC3544473
OpenAlexW2070206343

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.