MSCs, macrophages, and cancer: a dangerous ménage-à-trois.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

19 citing papers in PubMed, 37 citations in OpenAlex.

1. Glucose Metabolism and Tumor Microenvironment: Mechanistic Insights and Therapeutic Implications.International journal of molecular sciences · 2025
   Review
2. Proteomic profiling of iPSC and tissue-derived MSC secretomes reveal a global signature of inflammatory licensing.NPJ Regenerative medicine · 2025
   Article
3. Plasticity and crosstalk of mesenchymal stem cells and macrophages in immunomodulation in sepsis.Frontiers in immunology · 2024
   Review
4. Mesenchymal Stem Cells and PRP Therapy Favorize Leak Closure After Sleeve Gastrectomy in Zucker Rats.Obesity surgery · 2022
   Article
5. MSCs can be a double-edged sword in tumorigenesis.Frontiers in oncology · 2022
   Review
6. Three-Dimensional Culture System of Cancer Cells Combined with Biomaterials for Drug Screening.Cancers · 2020
   Review
7. Adult Stem Cell Functioning in the Tumor Micro-Environment.International journal of molecular sciences · 2019
   Review
8. Macrophage conditioned medium promotes colorectal cancer stem cell phenotype via the hedgehog signaling pathway.PloS one · 2018
   Article
9. Concise Review: Cancer Cells, Cancer Stem Cells, and Mesenchymal Stem Cells: Influence in Cancer Development.Stem cells translational medicine · 2017
   Review
10. Tumor-educated mesenchymal stem cells promote pro-metastatic phenotype.Oncotarget · 2017
    Review
11. Crosstalk between mesenchymal stem cells and macrophages in inflammatory bowel disease and associated colorectal cancer.Contemporary oncology (Poznan, Poland) · 2017
    Article
12. Mesenchymal stromal cells (MSCs) and colorectal cancer: a troublesome twosome for the anti-tumour immune response?Oncotarget · 2016
    Review
13. Mesenchymal Stem and Progenitor Cells in Normal and Dysplastic Hematopoiesis-Masters of Survival and Clonality?International journal of molecular sciences · 2016
    Review
14. Update on the treatment of focal segmental glomerulosclerosis in renal transplantation.World journal of transplantation · 2016
    Review
15. Stroma as an Active Player in the Development of the Tumor Microenvironment.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2015
    Article
16. The "Trojan Horse" approach to tumor immunotherapy: targeting the tumor microenvironment.Journal of immunology research · 2014
    Review
17. Macrophages in multiple myeloma: emerging concepts and therapeutic implications.Leukemia & lymphoma · 2013
    Review
18. Ménage à Trois in stress: DAMPs, redox and autophagy.Seminars in cancer biology · 2013
    Review
19. Tumor-associated macrophages: functional diversity, clinical significance, and open questions.Seminars in immunopathology · 2013
    Review

Corrections and comments

• Comment on
  Preactivation of human MSCs with TNF-α enhances tumor-suppressive activity.2012
• Comment on
  CCR2-dependent recruitment of macrophages by tumor-educated mesenchymal stromal cells promotes tumor development and is mimicked by TNFα.2012

Authors and funding

1 author at 1 institution in 1 country.

Funding

No grant is acknowledged in the PubMed record.

Abstract