ArticleBMC developmental biology2012
R-spondins are involved in the ovarian differentiation in a teleost, medaka (Oryzias latipes).
Article in BMC developmental biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 58 citations in OpenAlex.
- Multi- and transcriptomic changes of chronic exposure to bisphenol A reveals reproductive toxicity in male zebrafish.Fish physiology and biochemistry · 2023Article
- Effect of Exogenous Hormone onGenes · 2023Article
- Mechanisms of primordial follicle activation and new pregnancy opportunity for premature ovarian failure patients.Frontiers in physiology · 2023Review
- Proteome and Transcriptome Analysis of Gonads Reveals Intersex in Gigantidas haimaensis.BMC genomics · 2022Article
- Becoming female: Ovarian differentiation from an evolutionary perspective.Frontiers in cell and developmental biology · 2022Review
- Fish reproductive biology - Reflecting on five decades of fundamental and translational research.General and comparative endocrinology · 2021Review
- Transcriptome analysis of testis reveals the effects of developmental exposure to bisphenol a or 17α-ethinylestradiol in medaka (Oryzias latipes).Aquatic toxicology (Amsterdam, Netherlands) · 2020Article
- R-Spondin 2 Induces Odontogenic Differentiation of Dental Pulp Stem/Progenitor Cells via Regulation of Wnt/β-Catenin Signaling.Frontiers in physiology · 2020Article
- Identification of genomic regions regulating sex determination in Atlantic salmon using high density SNP data.BMC genomics · 2019Article
- Proteome and Transcriptome Analysis of Ovary, Intersex Gonads, and Testis Reveals Potential Key Sex Reversal/Differentiation Genes and Mechanism in Scallop Chlamys nobilis.Marine biotechnology (New York, N.Y.) · 2018Article
- Dimorphic expression of sex-related genes in different gonadal development stages of sterlet, Acipenser ruthenus, a primitive fish species.Fish physiology and biochemistry · 2017Article
- Integrated analysis of mRNA-seq and miRNA-seq reveals the potential roles of sex-biased miRNA-mRNA pairs in gonad tissue of dark sleeper (Odontobutis potamophila).BMC genomics · 2017Article
- Transcriptomic analysis of the differentiating ovary of the protogynous ricefield eel Monopterus albus.BMC genomics · 2017Article
- Histological and transcriptomic effects of 17α-methyltestosterone on zebrafish gonad development.BMC genomics · 2017Article
- Dmy initiates masculinity by altering Gsdf/Sox9a2/Rspo1 expression in medaka (Oryzias latipes).Scientific reports · 2016Article
- Rspo1-activated signalling molecules are sufficient to induce ovarian differentiation in XY medaka (Oryzias latipes).Scientific reports · 2016Article
- Large-scale transcriptome sequencing reveals novel expression patterns for key sex-related genes in a sex-changing fish.Biology of sex differences · 2015Article
- Comparative Transcriptome Analysis Reveals Sex-Biased Gene Expression in Juvenile Chinese Mitten Crab Eriocheir sinensis.PloS one · 2015Article
- The sex-specific transcriptome of the hermaphrodite sparid sharpsnout seabream (Diplodus puntazzo).BMC genomics · 2014Article
- Sequence and gene content of a large fragment of a lizard sex chromosome and evaluation of candidate sex differentiating gene R-spondin 1.BMC genomics · 2013Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn mammals, R-spondin (Rspo), an activator of the Wnt/β-catenin signaling pathway, has been shown to be involved in ovarian differentiation. However, the role of the Rspo/Wnt/β-catenin signaling pathway in fish gonads is still unknown.
resultsIn the present study, full-length cDNAs of Rspo1, 2 and 3 were cloned from the gonads of medaka (Oryzias latipes). The deduced amino acid sequences of mRspo1-3 were shown to have a similar structural organization. Phylogenetic analysis showed that Rspo1, 2 and 3 were specifically clustered into three distinct clads. Tissue distribution revealed that three Rspo genes were abundantly expressed in the brain and ovary. Real-time PCR analysis around hatching (S33-5dah) demonstrated that three Rspo genes were specifically enhanced in female gonads from S38. In situ hybridization (ISH) analysis demonstrated that three Rspo genes were expressed in the germ cell in ovary, but not in testis. Fluorescence multi-color ISH showed that Rspo1 was expressed in both somatic cells and germ cells at 10dah. Exposure to ethinylestradiol (EE2) in XY individuals for one week dramatically enhanced the expression of three Rspo genes both at 0dah and in adulthood.
conclusionsThese results suggest that the Rspo-activating signaling pathway is involved in the ovarian differentiation and maintenance in medaka.
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