ArticleReproductive biology and endocrinology : RB&E2012
Glutamate-induced obesity leads to decreased sperm reserves and acceleration of transit time in the epididymis of adult male rats.
Article in Reproductive biology and endocrinology : RB&E, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 37 citations in OpenAlex.
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- Hematological changes, oxidative stress assessment, and dysregulation of aquaporin-3 channel, prolactin, and oxytocin receptors in kidneys of lactating Wistar rats treated with monosodium glutamate.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Disruptive consequences of monosodium glutamate on male reproductive function: A review.Current research in toxicology · 2024Review
- Review
- Aerobic exercises regulate the epididymal anion homeostasis of high-fat diet-induced obese rats through TRPA1-mediated Cl- and HCO3- secretion†.Biology of reproduction · 2023Article
- Reporting The Effects of Exposure to Monosodium Glutamate on The Regulatory Peptides of The Hypothalamic-Pituitary-Gonadal Axis.International journal of fertility & sterility · 2021Review
- Congenital Anomalies Programmed by Maternal Diabetes and Obesity on Offspring of Rats.Frontiers in physiology · 2021Article
- Transcriptome Analysis of Testis from HFD-Induced Obese Rats (International journal of molecular sciences · 2020Article
- Review
- Proteomic alterations underlie an association with teratozoospermia in obese mice sperm.Reproductive biology and endocrinology : RB&E · 2019Article
- How much does obesity affect the male reproductive function?International journal of obesity supplements · 2019Review
- Intermittent resistance exercise and obesity, considered separately or combined, impair spermatic parameters in adult male Wistar rats.International journal of experimental pathology · 2018Article
- Grape juice concentrate alleviates epididymis and sperm damage in cadmium-intoxicated rats.International journal of experimental pathology · 2017Article
- Neonatal exposure to monosodium glutamate induces morphological alterations in suprachiasmatic nucleus of adult rat.International journal of experimental pathology · 2016Article
- Hyperleptinemia directly affects testicular maturation at different sexual stages in mice, and suppressor of cytokine signaling 3 is involved in this process.Reproductive biology and endocrinology : RB&E · 2014Article
- Male obesity and subfertility, is it really about increased adiposity?Asian journal of andrologyReview
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGiven the established fact that obesity interferes with male reproductive functions, the present study aimed to evaluate sperm production in the testis and storage in the epididymis in a glutamate-induced model of obesity.
methodsMale rats were treated neonatally with monosodium glutamate (MSG) at doses of 4 mg/kg subcutaneously, or with saline solution (control group), on postnatal days 2, 4, 6, 8 and 10. On day 120, obesity was confirmed by the Lee index in all MSG-treated rats. After this, all animals from the two experimental groups were anesthetized and killed to evaluate body and reproductive organ weights, sperm parameters, plasma hormone levels (FSH, LH and testosterone), testicular and epididymal histo-morphometry and histopathology.
resultsSignificant reductions in absolute and relative weights of testis, epididymis, prostate and seminal vesicle were noted in MSG-treated animals. In these same animals plasma testosterone and follicle-stimulating hormone (FSH) concentrations were decreased, as well as sperm counts in the testis and epididymis and seminiferous epithelium height and tubular diameter. The sperm transit time was accelerated in obese rats. However, the number of Sertoli cells per seminiferous tubule and stereological findings on the epididymis were not markedly changed by obesity.
conclusionsNeonatal MSG-administered model of obesity lowers sperm production and leads to a reduction in sperm storage in the epididymis of adult male rats. The acceleration of sperm transit time can have implications for the sperm quality of these rats.
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