ArticleBMC neurology2012
MRI findings are often missed in the diagnosis of Creutzfeldt-Jakob disease.
Article in BMC neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Prion disease mimicking rapidly progressive Alzheimer disease: case series and systematic review.Journal of neurology · 2026Pooled it
- Dementia With Lewy Bodies Phenocopy in a Case of RT-QuIC-Negative Creutzfeldt-Jakob Disease: Implications of Functional Anatomy.The Journal of neuropsychiatry and clinical neurosciences · 2025Article
- The Onset of Creutzfeldt-Jakob Disease After COVID-19: Navigating the Diagnostic Challenges and Clinical Evolution.Case reports in neurological medicine · 2025Article
- Assessing the newly proposed MRI criteria for diagnosing sporadic Creutzfeldt-Jakob disease.Neuroradiology · 2024Article
- Characterization of Laboratory-Confirmed Creutzfeldt-Jakob Disease From 3 Ontario Tertiary Care Centers Between 2012 and 2022: A Retrospective Cohort Study.Open forum infectious diseases · 2024Article
- Development of statistical auto-segmentation method for diffusion restriction gray matter lesions in patients with newly diagnosed sporadic Creutzfeldt-Jakob disease.Scientific reports · 2024Article
- Real-time quaking-induced conversion assays for prions: Applying a sensitive but imperfect test in clinical practice.European journal of neurology · 2023Article
- Gene expression and epigenetic markers of prion diseases.Cell and tissue research · 2023Review
- Creutzfeldt-Jakob disease in a post-COVID-19 patient: did SARS-CoV-2 accelerate the neurodegeneration?The Egyptian journal of neurology, psychiatry and neurosurgery · 2023Article
- Sporadic Creutzfeldt-Jakob Disease in a Patient With Multiple Sclerosis: A Case Report.Cureus · 2022Article
- Rapidly progressive dementias - aetiologies, diagnosis and management.Nature reviews. Neurology · 2022Review
- Validation of Revised International Creutzfeldt-Jakob Disease Surveillance Network Diagnostic Criteria for Sporadic Creutzfeldt-Jakob Disease.JAMA network open · 2022Article
- The Use of Real-Time Quaking-Induced Conversion for the Diagnosis of Human Prion Diseases.Frontiers in aging neuroscience · 2022Review
- Creutzfeldt-Jakob disease with neuroleptic malignant syndrome.Clinical case reports · 2021Article
- Premortem diagnosis of pathologically confirmed sporadic Creutzfeldt-Jakob disease.Clinical case reports · 2021Article
- Creutzfeldt-Jakob disease as a cause of dementia.BMJ case reports · 2021Article
- Review
- Subtype Diagnosis of Sporadic Creutzfeldt-Jakob Disease with Diffusion Magnetic Resonance Imaging.Annals of neurology · 2021Article
- Biomarkers and diagnostic guidelines for sporadic Creutzfeldt-Jakob disease.The Lancet. Neurology · 2021Review
- A patient with sporadic Creutzfeldt-Jakob disease: challenges of rare diseases in the COVID-19 era.Oxford medical case reports · 2020Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundEstablishing a confident clinical diagnosis before an advanced stage of illness can be difficult in Creutzfeldt-Jakob disease (CJD) but unlike common causes of dementia, prion diseases can often be diagnosed by identifying characteristic MRI signal changes. However, it is not known how often CJD-associated MRI changes are identified at the initial imaging report, whether the most sensitive sequences are used, and what impact MRI-diagnosis has on prompt referral to clinical trial-like studies.
methodsWe reviewed the MRI scans of 103 patients with CJD referred to the National Prion Clinic since 2007 and reviewed the presence of CJD-associated changes, compared these findings with the formal report from the referring centre and reviewed the types of sequence performed.
resultsIn sCJD we found CJD-associated MRI changes in 83 of 91 cases (91% sensitivity). However, the referring centres documented CJD-associated MRI changes in 43 of the sCJD cases (47% sensitivity). The most common region not documented by referring centres was the cortex (23 of 68 sCJD cases), but there was a statistically significant discrepancy in all regions (p<0.0001). Patients in whom MRI abnormalities were missed by the referring hospital were more advanced at the time of recruitment to a clinical trial-like study (p=0.03).
conclusionsCJD-associated MRI changes are often not documented on the formal investigation report at the referring centre. This is important as delay makes enrolment to clinical trials futile because of highly advanced disease. If a diagnosis of CJD is suspected, even if the initial imaging is reported as normal, a specialist MRI review either by an experienced neuroradiologist or by a prion disease specialist unit could facilitate earlier diagnosis.
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