ArticleCell proliferation2013
Elastic three-dimensional poly (ε-caprolactone) nanofibre scaffold enhances migration, proliferation and osteogenic differentiation of mesenchymal stem cells.
Article in Cell proliferation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed.
- In Vivo Cell Migration and Growth Within Electrospun Porous Nanofibrous Scaffolds with Different Pore Sizes in a Mouse Pouch Model.Journal of functional biomaterials · 2025Article
- 3D Culture of MSCs for Clinical Application.Bioengineering (Basel, Switzerland) · 2024Review
- Optimizing PCL/PLGA Scaffold Biocompatibility Using Gelatin from Bovine, Porcine, and Fish Origin.Gels (Basel, Switzerland) · 2023Article
- A 3D-Printed Dual Driving Forces Scaffold with Self-Promoted Cell Absorption for Spinal Cord Injury Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Personalized additive manufacturing of devices for the management of enteroatmospheric fistulas.Bioengineering & translational medicine · 2023Article
- 3D Electrospun Polycaprolactone Scaffolds to Assess Human Periodontal Ligament Cells Mechanobiological Behaviour.Biomimetics (Basel, Switzerland) · 2023Article
- Self-assembling peptides with hBMP7 biological activity promote the differentiation of ADSCs into nucleus pulposus-like cells.Journal of orthopaedic surgery and research · 2022Article
- Article
- Characterizing cell recruitment into isotropic and anisotropic biomaterials by quantification of spatial density gradientsFrontiers in bioengineering and biotechnology · 2022Article
- Porous 3D Scaffolds Enhance MSC Vitality and Reduce Osteoclast Activity.Molecules (Basel, Switzerland) · 2021Article
- The effects of locomotion on bone marrow mesenchymal stem cell fate: insight into mechanical regulation and bone formation.Cell & bioscience · 2021Review
- Impact of 3D cell culture on bone regeneration potential of mesenchymal stromal cells.Stem cell research & therapy · 2021Review
- Enhancing Cellular Infiltration on Fluffy Polyaniline-Based Electrospun Nanofibers.Frontiers in bioengineering and biotechnology · 2021Article
- Using a bio-scanner and 3D printing to create an innovative custom made approach for the management of complex entero-atmospheric fistulas.Scientific reports · 2020Article
- Article
- Dynamic creep properties of a novel nanofiber hernia mesh in abdominal wall repair.Hernia : the journal of hernias and abdominal wall surgery · 2019Article
- Reduced graphene oxide: osteogenic potential for bone tissue engineering.IET nanobiotechnology · 2019Article
- Osteoinductive 3D scaffolds prepared by blend centrifugal spinning for long-term delivery of osteogenic supplements.RSC advances · 2018Article
- Composite 3D printed scaffold with structured electrospun nanofibers promotes chondrocyte adhesion and infiltration.Cell adhesion & migration · 2018Article
- Dry versus hydrated collagen scaffolds: are dry states representative of hydrated states?Journal of materials science. Materials in medicine · 2018Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesWe prepared 3D poly (ε-caprolactone) (PCL) nanofibre scaffolds and tested their use for seeding, proliferation, differentiation and migration of mesenchymal stem cell (MSCs). MATERIALS AND
methods3D nanofibres were prepared using a special collector for common electrospinning; simultaneously, a 2D PCL nanofibre layer was prepared using a classic plain collector. Both scaffolds were seeded with MSCs and biologically tested. MSC adhesion, migration, proliferation and osteogenic differentiation were investigated.
resultsThe 3D PCL scaffold was characterized by having better biomechanical properties, namely greater elasticity and resistance against stress and strain, thus this scaffold will be able to find broad applications in tissue engineering. Clearly, while nanofibre layers of the 2D scaffold prevented MSCs from migrating through the conformation, cells infiltrated freely through the 3D scaffold. MSC adhesion to the 3D nanofibre PCL layer was also statistically more common than to the 2D scaffold (P < 0.05), and proliferation and viability of MSCs 2 or 3 weeks post-seeding, were also greater on the 3D scaffold. In addition, the 3D PCL scaffold was also characterized by displaying enhanced MSC osteogenic differentiation.
conclusionsWe draw the conclusion that all positive effects observed using the 3D PCL nanofibre scaffold are related to the larger fibre surface area available to the cells. Thus, the proposed 3D structure of the nanofibre layer will find a wide array of applications in tissue engineering and regenerative medicine.
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