ArticleGenetic testing and molecular biomarkers2013
Association analysis of two single-nucleotide polymorphisms of the RELN gene with autism in the South African population.
Article in Genetic testing and molecular biomarkers, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 3 of them syntheses that pooled it.
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Who cites it
8 citing papers in PubMed, 3 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- A systematic review of common genetic variation and biological pathways in autism spectrum disorder.BMC neuroscience · 2021Pooled it
- Association of Allelic Variants of the Reelin Gene with Autistic Spectrum Disorder: A Systematic Review and Meta-Analysis of Candidate Gene Association Studies.International journal of environmental research and public health · 2020Pooled it
- A Systematic Review of Research on Autism Spectrum Disorders in Sub-Saharan Africa.Behavioural neurology · 2016Pooled it
- Genetic etiology of autism spectrum disorder in the African population: a scoping review.Frontiers in genetics · 2024Article
- Article
- A potential role of fatty acid binding protein 4 in the pathophysiology of autism spectrum disorder.Brain communications · 2020Article
- Autism spectrum disorder in sub-saharan africa: A comprehensive scoping review.Autism research : official journal of the International Society for Autism Research · 2017Article
- Mapping pathological phenotypes in reelin mutant mice.Frontiers in pediatrics · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAutism (MIM209850) is a neurodevelopmental disorder characterized by a triad of impairments, namely impairment in social interaction, impaired communication skills, and restrictive and repetitive behavior. A number of family and twin studies have demonstrated that genetic factors play a pivotal role in the etiology of autistic disorder. Various reports of reduced levels of reelin protein in the brain and plasma in autistic patients highlighted the role of the reelin gene (RELN) in autism. There is no such published study on the South African (SA) population.
aimsThe aim of the present study was to find the genetic association of intronic rs736707 and exonic rs362691 (single-nucleotide polymorphisms [SNPs] of the RELN gene) with autism in a SA population.
methodsGenomic DNA was isolated from cheek cell swabs from autistic (136) as well as control (208) subjects. The TaqMan(®) Real-Time polymerase chain reaction and genotyping assay was utilized to determine the genotypes.
resultsA significant association of SNP rs736707, but not for SNP rs362691, with autism in the SA population is observed.
conclusionThere might be a possible role of RELN in autism, especially for SA populations. The present study represents the first report on genetic association studies on the RELN gene in the SA population.
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