ArticleMetabolic syndrome and related disorders2013
Triglyceride-based screening tests fail to recognize cardiometabolic disease in African immigrant and African-American men.
Article in Metabolic syndrome and related disorders, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- Metabolic syndrome in youth with bipolar spectrum disorders treated with second-generation antipsychotics: baseline results from the community-based pragmatic MOBILITY Trial.European child & adolescent psychiatry · 2025Trial
- Time in the United States and walking for physical activity among Black Californians: Findings from the California Health Interview Survey (2012-2017).Journal of migration and health · 2025Article
- Material needs security and cardiovascular risk factors in rural South Africa.BMC public health · 2024Observational
- Prevalence of the metabolic syndrome and its components in secondary school student population in the city of Douala, Cameroon.Journal of public health in Africa · 2023Article
- Genes, environment, and African ancestry in cardiometabolic disorders.Trends in endocrinology and metabolism: TEM · 2023Review
- Endocrine Health and Health Care Disparities in the Pediatric and Sexual and Gender Minority Populations: An Endocrine Society Scientific Statement.The Journal of clinical endocrinology and metabolism · 2023Article
- Black Nativity and Health Disparities: A Research Paradigm for Understanding the Social Determinants of Health.International journal of environmental research and public health · 2022Review
- Waist circumference thresholds predicting incident dysglycaemia and type 2 diabetes in Black African men and women.Diabetes, obesity & metabolism · 2022Article
- Stress Measured by Allostatic Load Varies by Reason for Immigration, Age at Immigration, and Number of Children: The Africans in America Study.International journal of environmental research and public health · 2020Article
- Body adiposity measured by bioelectrical impedance is an alternative to dual-energy x-ray absorptiometry in black Africans: The Africans in America Study.Nutrition (Burbank, Los Angeles County, Calif.) · 2020Article
- Comparison of Cardiovascular Disease Risk Factors Among African Immigrants and African Americans: An Analysis of the 2010 to 2016 National Health Interview Surveys.Journal of the American Heart Association · 2020Article
- Triglyceride Paradox Is Related to Lipoprotein Size, Visceral Adiposity and Stearoyl-CoA Desaturase Activity in Black Versus White Women.Circulation research · 2020Article
- Metabolic characteristics of Africans with normal glucose tolerance and elevated 1-hour glucose: insight from the Africans in America study.BMJ open diabetes research & care · 2020Article
- Allostatic Load: Importance, Markers, and Score Determination in Minority and Disparity Populations.Journal of urban health : bulletin of the New York Academy of Medicine · 2019Article
- A Review of Diabetes Prediction Equations in African Descent Populations.Frontiers in endocrinology · 2019Review
- Stress Measured by Allostatic Load Score Varies by Reason for Immigration: The Africans in America Study.Journal of racial and ethnic health disparities · 2018Article
- Do current guidelines for waist circumference apply to black Africans? Prediction of insulin resistance by waist circumference among Africans living in America.BMJ global health · 2018Article
- Diabetes: T2DM risk prediction in populations of African descent.Nature reviews. Endocrinology · 2016Article
- Cardiometabolic Health in African Immigrants to the United States: A Call to Re-examine Research on African-descent populations.Ethnicity & disease · 2015Review
- Detection of abnormal glucose tolerance in Africans is improved by combining A1C with fasting glucose: the Africans in America Study.Diabetes care · 2015Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe prevalence of cardiometabolic disease in Africa now rivals that of Western nations. Therefore, screening programs that lead to effective prevention of cardiometabolic disease in Africans is imperative. Most screening tests for cardiometabolic disease use triglyceride (TG) levels as a criterion. However, the failure rate of TG-based screening tests in African Americans is high. In Africans, the efficacy of TG-based screening tests is unknown. Our goal was to determine the association between hypertriglyceridemia (TG ≥150 mg/dL) and cardiometabolic disease in African and African-American men. RESEARCH DESIGN AND
methodsThis was a cross-sectional study of 155 men (80 African immigrants, 75 African Americans) [age, 35±9 years, mean±standard deviation (SD), body mass index (BMI) 28.5±5.2 kg/m(2)] who self-identified as healthy. Lipid profiles were performed. Glucose tolerance and insulin resistance was determined by oral glucose tolerance tests (OGTT) and the insulin sensitivity index (S(I)), respectively. Cardiometabolic disease was defined by four possible subtypes--prediabetes, diabetes, insulin resistance, or metabolic triad [hyperinsulinemia, hyperapolipoprotein B, small low-density lipoprotein (LDL) particles].
resultsTG levels were higher in men with cardiometabolic disease than without (88±43 versus 61±26 mg/dL, P<0.01). However, <10% of men with cardiometabolic disease had TG ≥150 mg/dL. Even within each cardiometabolic disease subtype, the prevalence of TG ≥150 mg/dL was <10%. Furthermore, TG levels in the 5% of men identified by OGTT as diabetic were ≤100 mg/dL (mean 71±24, range 45-100 mg/dL).
conclusionsHypertriglyceridemia is a poor marker of cardiometabolic disease in men of African descent. Therefore TG-based screening tests fail to identify both African immigrants and African-American men with cardiometabolic disease. As a consequence, the opportunity for early intervention and prevention is lost.
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