ReviewACS chemical biology2013
Fat chance! Getting a grip on a slippery modification.
Review in ACS chemical biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Differential alkylation-based redox proteomics--Lessons learnt.Redox biology · 2015Pooled it
- Protein Lipidation Types: Current Strategies for Enrichment and Characterization.International journal of molecular sciences · 2022Review
- Amphiphilic Iodine(III) Reagents for the Lipophilization of Peptides in Water.Angewandte Chemie (International ed. in English) · 2021Article
- Article
- Polycystin-1, the product of the polycystic kidney disease gene PKD1, is post-translationally modified by palmitoylation.Molecular biology reports · 2018Article
- Protein depalmitoylases.Critical reviews in biochemistry and molecular biology · 2018Review
- Article
- Roles of palmitoylation in axon growth, degeneration and regeneration.Journal of neuroscience research · 2017Review
- APT2 Inhibition Restores Scribble Localization and S-Palmitoylation in Snail-Transformed Cells.Cell chemical biology · 2017Article
- A Quantitative Mass-Spectrometry Platform to Monitor Changes in Cysteine Reactivity.Methods in molecular biology (Clifton, N.J.) · 2017Article
- The role of a conserved membrane proximal cysteine in altering αPS2CβPS integrin diffusion.Physical biology · 2016Article
- Correlated S-palmitoylation profiling of Snail-induced epithelial to mesenchymal transition.Molecular bioSystems · 2016Article
- Proteomic analysis of fatty-acylated proteins.Current opinion in chemical biology · 2016Review
- Global Analysis of Palmitoylated Proteins in Toxoplasma gondii.Cell host & microbe · 2015Article
- Identification of a Novel Sequence Motif Recognized by the Ankyrin Repeat Domain of zDHHC17/13 S-Acyltransferases.The Journal of biological chemistry · 2015Article
- Involvement of RARRES3 in the regulation of Wnt proteins acylation and signaling activities in human breast cancer cells.Cell death and differentiation · 2015Article
- Chemical reporters for exploring protein acylation.Biochemical Society transactions · 2015Review
- The physiology of protein S-acylation.Physiological reviews · 2015Review
- Bifunctional fatty acid chemical reporter for analyzing S-palmitoylated membrane protein-protein interactions in mammalian cells.Journal of the American Chemical Society · 2015Article
- Chemoproteomics reveals Toll-like receptor fatty acylation.BMC biology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Protein palmitoylation describes the post-translational fatty acyl thioesterification of cellular cysteine residues and is critical for the localization, trafficking, and compartmentalization of a large number of membrane proteins. This labile thioester modification facilitates a dynamic acylation cycle that directionally traffics key signaling complexes, receptors, and channels to select membrane compartments. Chemical enrichment and advanced mass spectrometry-based proteomics methods have highlighted a pervasive role for palmitoylation across all eukaryotes, including animals, plants, and parasites. Emerging chemical tools promise to open new avenues to study the enzymes, substrates, and dynamics of this distinct post-translational modification.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.