ArticleBiomacromolecules2013
Self-assembled pH-sensitive cholesteryl pullulan nanogel as a protein delivery vehicle.
Article in Biomacromolecules, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 135 citations in OpenAlex.
- Polymeric soft materials with molecular recognition: from static binding to dynamic functions in gels, particles, and interfaces.Science and technology of advanced materials · 2026Review
- Glycopolypeptide Coordinated Nanovaccine: Fabrication, Characterization, and Antitumor Immune Response.Chem & bio engineering · 2024Article
- Biomedicine Innovations and Its Nanohydrogel Classifications.Pharmaceutics · 2022Review
- Green Hydrogel Synthesis: Emphasis on Proteomics and Polymer Particle-Protein Interaction.Polymers · 2022Review
- Article
- Next-Generation Diprovocims with Potent Human and Murine TLR1/TLR2 Agonist Activity That Activate the Innate and Adaptive Immune Response.Journal of medicinal chemistry · 2022Article
- Stimuli-responsive polypeptide nanogels for trypsin inhibition.Beilstein journal of nanotechnology · 2022Article
- Synthesis of Nanogels: Current Trends and Future Outlook.Gels (Basel, Switzerland) · 2021Review
- Review
- Thermoresponsive Nanogels Based on Different Polymeric Moieties for Biomedical Applications.Gels (Basel, Switzerland) · 2020Review
- Conformation of Pullulan in Aqueous Solution Studied by Small-Angle X-Ray Scattering.Polymers · 2020Article
- Nanohydrogels Based on Self-Assembly of Cationic Pullulan and Anionic Dextran Derivatives for Efficient Delivery of Piroxicam.Pharmaceutics · 2019Article
- Review of polysaccharide particle-based functional drug delivery.Carbohydrate polymers · 2019Review
- Research progress of self-assembled nanogel and hybrid hydrogel systems based on pullulan derivatives.Drug delivery · 2018Review
- Combinatorial approaches in post-polymerization modification for rational development of therapeutic delivery systems.Acta biomaterialia · 2018Review
- Preparation of Biodegradable Oligo(lactide)s-Grafted Dextran Nanogels for Efficient Drug Delivery by Controlling Intracellular Traffic.International journal of molecular sciences · 2018Article
- Pullulan microbeads/Si-HPMC hydrogel injectable system for the sustained delivery of GDF-5 and TGF-β1: new insight into intervertebral disc regenerative medicine.Drug delivery · 2017Article
- The Potential of Stimuli-Responsive Nanogels in Drug and Active Molecule Delivery for Targeted Therapy.Gels (Basel, Switzerland) · 2017Review
- Affinity-controlled protein encapsulation into sub-30 nm telodendrimer nanocarriers by multivalent and synergistic interactions.Biomaterials · 2016Article
- Polysaccharide-based micelles for drug delivery.Pharmaceutics · 2013Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
A self-assembled nanogel, derived from an acid-labile cholesteryl-modified pullulan (acL-CHP), was prepared by grafting vinyl ether-cholesterol substituents onto a 100 kD pullulan main chain polymer backbone. Stable nanogels are formed by acL-CHP self-assemblies at neutral pH. The hydrodynamic radius of the nanogels, observed to be 26.5 ± 5.1 nm at pH 7.0, increased by ~135% upon acidification of the solution to pH 4.0. SEC analysis of the acL-CHP nanogel at pH 4.0 showed that the grafts were nearly 80% degraded after 24 h, whereas little or no degradation was observed over the same time period for a pH stable analog (acS-CHP) at pH 4.0 or the acL-CHP at pH 7.0. Complexation of BSA with the acL-CHP nanogel was observed at pH 7.0 with subsequent release of the protein upon acidification. These findings suggest that stimuli-responsive, self-assembled nanogels can release protein cargo in a manner that is controlled by the degradation rate of the cholesterol-pullulan grafting moiety.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.