ArticleBiology open2012
Fss/Tbx6 is required for central dermomyotome cell fate in zebrafish.
Article in Biology open, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Article
- Thyroid hormone regulates abrupt skin morphogenesis during zebrafish postembryonic development.Developmental biology · 2021Article
- Evolution of Somite Compartmentalization: A View FromFrontiers in cell and developmental biology · 2021Article
- Notochordal Signals Establish Phylogenetic Identity of the Teleost Spine.Current biology : CB · 2020Article
- Fgf-driven Tbx protein activities directly induceDevelopment (Cambridge, England) · 2020Article
- Role of somite patterning in the formation of Weberian apparatus and pleural rib in zebrafish.Journal of anatomy · 2020Article
- Shaping the zebrafish myotome by intertissue friction and active stress.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Characterization of paralogousGene: X · 2019Article
- Mitochondria in Embryogenesis: An Organellogenesis Perspective.Frontiers in cell and developmental biology · 2019Article
- Myotome adaptability confers developmental robustness to somitic myogenesis in response to fibre number alteration.Developmental biology · 2017Article
- tbx6l and tbx16 are redundantly required for posterior paraxial mesoderm formation during zebrafish embryogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2017Article
- Cellular dynamics of regeneration reveals role of two distinct Pax7 stem cell populations in larval zebrafish muscle repair.Disease models & mechanisms · 2016Article
- Tbx16 and Msgn1 are required to establish directional cell migration of zebrafish mesodermal progenitors.Developmental biology · 2015Article
- Time course and side-by-side analysis of mesodermal, pre-myogenic, myogenic and differentiated cell markers in the chicken model for skeletal muscle formation.Journal of anatomy · 2015Article
- Tbx6, Mesp-b and Ripply1 regulate the onset of skeletal myogenesis in zebrafish.Development (Cambridge, England) · 2015Article
- Origins of adult pigmentation: diversity in pigment stem cell lineages and implications for pattern evolution.Pigment cell & melanoma research · 2015Review
- Novel ENU-Induced Mutation in Tbx6 Causes Dominant Spondylocostal Dysostosis-Like Vertebral Malformations in the Rat.PloS one · 2015Article
- Chevron formation of the zebrafish muscle segments.The Journal of experimental biology · 2014Article
- The T-box gene family: emerging roles in development, stem cells and cancer.Development (Cambridge, England) · 2014Review
- The zebrafish anatomy and stage ontologies: representing the anatomy and development of Danio rerio.Journal of biomedical semantics · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The dermomyotome is a pool of progenitor cells on the surface of the myotome. In zebrafish, dermomyotome precursors (anterior border cells, ABCs) can be first identified in the anterior portion of recently formed somites. They must be prevented from undergoing terminal differentiation during segmentation, even while mesodermal cells around them respond to signaling cues and differentiate.T-box containing transcription factors regulate many aspects of mesoderm fate including segmentation and somite patterning. The fused somites (fss) gene is the zebrafish ortholog of tbx6. We demonstrate that in addition to its requirement for segmentation, fss/tbx6 is also required for the specification of ABCs and subsequently the central dermomyotome. The absence of Tbx6-dependent central dermomyotome cells in fss/tbx6 mutants is spatially coincident with a patterning defect in the myotome.Using transgenic fish with a heat-shock inducible tbx6 gene in the fss/tbx6 mutant background, we further demonstrate that ubiquitous fss/tbx6 expression has spatially distinct effects on recovery of the dermomyotome and segment boundaries, suggesting that the mechanism of Fss/Tbx6 action is distinct with respect to dermomyotome development and segmentation.We propose that Fss/Tbx6 is required for preventing myogenic differentiation of central dermomyotome precursors before and after segmentation and that central dermomyotome cells represent a genetically and functionally distinct subpopulation within the zebrafish dermomyotome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.