ArticleBiology open2012
A trade-off between natural and acquired antibody production in a reptile: implications for long-term resistance to disease.
Article in Biology open, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 58 citations in OpenAlex.
- High-Throughput Sequencing-Based Assessment of Intestinal Parasitic Infections in Economically and Medicinally Valuable Captive Tokay Gecko (Animals : an open access journal from MDPI · 2025Article
- Article
- Antigen specificity affects analysis of natural antibodies.Frontiers in immunology · 2024Article
- Evolutionary trade-off between innate and acquired immune defences in birds.Frontiers in zoology · 2023Article
- Sex-specific innate immunity and ageing in long-lived fresh water turtles (Kinosternon flavescens: Kinosternidae).Immunity & ageing : I & A · 2023Article
- Immunity in Sea Turtles: Review of a Host-Pathogen Arms Race Millions of Years in the Running.Animals : an open access journal from MDPI · 2023Review
- 450 million years in the making: mapping the evolutionary foundations of germinal centers.Frontiers in immunology · 2023Review
- Adaptive evolution of major histocompatibility complex class I immune genes and disease associations in coastal juvenile sea turtles.Royal Society open science · 2022Article
- Bovine Natural Antibody Relationships to Specific Antibodies andVeterinary sciences · 2022Article
- Immunosenescence and its influence on reproduction in a long-lived vertebrate.The Journal of experimental biology · 2020Article
- Immune and sex-biased gene expression in the threatened Mojave desert tortoise, Gopherus agassizii.PloS one · 2020Article
- A tale of two islands: evidence for impaired stress response and altered immune functions in an insular pit viper following ecological disturbance.Conservation physiology · 2020Article
- Complex immune responses and molecular reactions to pathogens and disease in a desert reptile (Ecology and evolution · 2019Article
- Article
- Chronic disease in the Mojave desert tortoise: Host physiology and recrudescence obscure patterns of pathogen transmission.Ecology and evolution · 2017Article
- Detection of bacterial-reactive natural IgM antibodies in desert bighorn sheep populations.PloS one · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vertebrate immune systems are understood to be complex and dynamic, with trade-offs among different physiological components (e.g., innate and adaptive immunity) within individuals and among taxonomic lineages. Desert tortoises (Gopherus agassizii) immunised with ovalbumin (OVA) showed a clear trade-off between levels of natural antibodies (NAbs; innate immune function) and the production of acquired antibodies (adaptive immune function). Once initiated, acquired antibody responses included a long-term elevation in antibodies persisting for more than one year. The occurrence of either (a) high levels of NAbs or (b) long-term elevations of acquired antibodies in individual tortoises suggests that long-term humoral resistance to pathogens may be especially important in this species, as well as in other vertebrates with slow metabolic rates, concomitantly slow primary adaptive immune responses, and long life-spans.
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Registered trials
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