ArticleGastroenterology research and practice2012
The Correlation between Microsatellite Instability and the Features of Sporadic Colorectal Cancer in the North Part of Iran.
Article in Gastroenterology research and practice, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Correlation of the expression of mismatch repair proteins, CDX2, and SATB2 with the clinicopathological parameters of patients with colorectal carcinoma.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Validated nomograms for non-metastatic colorectal cancer prognosis prediction: a population-based study.Frontiers in oncology · 2025Article
- Mutation Analysis of KRAS and BRAF in Iranian Colorectal Cancer patients: A Novel Variant in Exon 15 of BRAF.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Microsatellite Instability and Colorectal Cancer, Immunohistochemical and Molecular Evaluation by Using DNA Sequencing: A Single Center Experience.Iranian journal of pathology · 2021Article
- Genomic amplification of chromosome 20q13.33 is the early biomarker for the development of sporadic colorectal carcinoma.BMC medical genomics · 2020Article
- Microsatellite Instability and Life Style Factors in Sporadic Colorectal Cancer.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- The correlation between DNA mismatch repair status and the clinicopathological and molecular features of Chinese sporadic colorectal cancer.Translational cancer research · 2020Article
- Genetic and molecular origins of colorectal Cancer among the Iranians: an update.Diagnostic pathology · 2018Review
- Deterministic Role of CEA and MSI Status in Predicting Outcome of CRC Patients: a Perspective Study Amongst Hospital Attending Eastern Indian Populations.Indian journal of surgical oncology · 2017Article
- Mismatch Repair Proteins and Microsatellite Instability in Colorectal Carcinoma (MLH1, MSH2, MSH6 and PMS2): Histopathological and Immunohistochemical Study.Open access Macedonian journal of medical sciences · 2017Article
- Low Level of Microsatellite Instability Correlates with Poor Clinical Prognosis in Stage II Colorectal Cancer Patients.Journal of oncology · 2016Article
- Molecular analysis of Iranian colorectal cancer patients at risk for Lynch syndrome: a new molecular, clinicopathological feature.Journal of gastrointestinal cancer · 2015Article
- Tumor microsatellite instability and clinicopathologic features in Iranian colorectal cancer patients at risk for Lynch syndrome.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2015Article
- Microsatellite instability and promoter hypermethylation in colorectal cancer in India.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background. The aim of this study was to determine the correlation between MSI and sporadic colorectal cancer in Guilan province, North part of Iran. Materials and Methods. A total of 96 patients who underwent resection for sporadic colorectal cancer in Guilan province were studied. No patients had positive family history of cancers. The frequencies of MSI were analyzed by testing the BAT-26 and BAT-25 markers. Results. MSI analysis revealed that 22.9% of the tumors (22 patients) were microsatellite instability positive and 77.1% (74 patients) were microsatellite instability negative. The highest rate of MSI (40.9%) was found in the rectal region. MSI-H status was seen more frequently in distal tumors (P = 0.04, odds ratio = 3.13, 0.96-10.14). Conclusions. Distal tumor location and MSI may associate with special clinicopathological features. It seems that there may be correlation with underlying genetic and immunologic mechanisms.
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