ArticleProceedings of the National Academy of Sciences of the United States of America2012
Topological specificity and hierarchical network of the circadian calcium rhythm in the suprachiasmatic nucleus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.
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Who cites it
77 citing papers in PubMed, 1 synthesis or guideline pooled it, 107 citations in OpenAlex.
- A meta-analysis including dose-response relationship between night shift work and the risk of colorectal cancer.Oncotarget · 2015Pooled it
- Interpretable machine learning reveals hemispheric asymmetry of state switching in the suprachiasmatic nucleus.Patterns (New York, N.Y.) · 2026Article
- CaMKIIα mediates feedback effects of wheel-running activity on the circadian pacemaker in mice.Scientific reports · 2026Article
- Article
- A High-Throughput Live Imaging Platform to Investigate Circuit-Dependent Regulation of Circadian Rhythms in Brain Tissue.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Reconsidering mammalian circadian organization.Neurobiology of sleep and circadian rhythms · 2026Article
- Human Cerebral Blood Flow Activity with Diurnal Variation Differentially Correlated with the Suprachiasmatic Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Diurnality reconfigures circadian network dynamics in the suprachiasmatic nucleus.bioRxiv : the preprint server for biology · 2026Article
- Suprachiasmatic Nuclei Possess Glucocorticoid Receptors That Activate Downstream Signaling Pathways but Do Not Entrain Their Circadian Clock.Acta physiologica (Oxford, England) · 2026Article
- On the origin and evolution of the dual oscillator model underlying the photoperiodic clockwork in the suprachiasmatic nucleus.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Review
- System-level time computation and representation in the suprachiasmatic nucleus revealed by large-scale calcium imaging and machine learning.Cell research · 2024Article
- Extensive soma-soma plate-like contact sites (ephapses) connect suprachiasmatic nucleus neurons.The Journal of comparative neurology · 2024Article
- The Suprachiasmatic Nucleus at 50: Looking Back, Then Looking Forward.Journal of biological rhythms · 2024Review
- Diurnal Variation of Brain Activity in the Human Suprachiasmatic Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Cold-induced suspension and resetting of CaiScience · 2023Article
- In vivo recording of suprachiasmatic nucleus dynamics reveals a dominant role of arginine vasopressin neurons in circadian pacesetting.PLoS biology · 2023Article
- The role of the circadian rhythms in critical illness with a focus on acute pancreatitis.Heliyon · 2023Review
- Arginine-vasopressin-expressing neurons in the murine suprachiasmatic nucleus exhibit a circadian rhythm in network coherence in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Network-driven intracellular cAMP coordinates circadian rhythm in the suprachiasmatic nucleus.Science advances · 2023Article
- In-phasic cytosolic-nuclear CaFrontiers in neuroscience · 2023Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The circadian pacemaker in the hypothalamic suprachiasmatic nucleus (SCN) is a hierarchical multioscillator system in which neuronal networks play crucial roles in expressing coherent rhythms in physiology and behavior. However, our understanding of the neuronal network is still incomplete. Intracellular calcium mediates the input signals, such as phase-resetting stimuli, to the core molecular loop involving clock genes for circadian rhythm generation and the output signals from the loop to various cellular functions, including changes in neurotransmitter release. Using a unique large-scale calcium imaging method with genetically encoded calcium sensors, we visualized intracellular calcium from the entire surface of SCN slice in culture including the regions where autonomous clock gene expression was undetectable. We found circadian calcium rhythms at a single-cell level in the SCN, which were topologically specific with a larger amplitude and more delayed phase in the ventral region than the dorsal. The robustness of the rhythm was reduced but persisted even after blocking the neuronal firing with tetrodotoxin (TTX). Notably, TTX dissociated the circadian calcium rhythms between the dorsal and ventral SCN. In contrast, a blocker of gap junctions, carbenoxolone, had only a minor effect on the calcium rhythms at both the single-cell and network levels. These results reveal the topological specificity of the circadian calcium rhythm in the SCN and the presence of coupled regional pacemakers in the dorsal and ventral regions. Neuronal firings are not necessary for the persistence of the calcium rhythms but indispensable for the hierarchical organization of rhythmicity in the SCN.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.