ArticleProceedings of the National Academy of Sciences of the United States of America2012
Contribution of active hair-bundle motility to nonlinear amplification in the mammalian cochlea.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- Article
- The continued importance of comparative auditory research to modern scientific discovery.Hearing research · 2023Review
- The impact of targeted ablation of one row of outer hair cells and Deiters' cells on cochlear amplification.Journal of neurophysiology · 2022Article
- Salicylate-induced changes in organ of Corti vibrations.Hearing research · 2022Article
- A Preliminary Prototype High-Speed Feedback Control of an Artificial Cochlear Sensory Epithelium Mimicking Function of Outer Hair Cells.Micromachines · 2020Article
- Characterisation of the static offset in the travelling wave in the cochlear basal turn.Pflugers Archiv : European journal of physiology · 2020Article
- Article
- Reducing tectorial membrane viscoelasticity enhances spontaneous otoacoustic emissions and compromises the detection of low level sound.Scientific reports · 2019Article
- Semicircular canal biomechanics in health and disease.Journal of neurophysiology · 2019Review
- Organ of Corti vibration within the intact gerbil cochlea measured by volumetric optical coherence tomography and vibrometry.Journal of neurophysiology · 2018Article
- Hidden cochlear impairments.Journal of otology · 2018Review
- Frequency sensitivity in mammalian hearing from a fundamental nonlinear physics model of the inner ear.Scientific reports · 2017Article
- Two-Dimensional Cochlear Micromechanics Measured In Vivo Demonstrate Radial Tuning within the Mouse Organ of Corti.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Perception as a closed-loop convergence process.eLife · 2016Article
- Finite-element model of the active organ of Corti.Journal of the Royal Society, Interface · 2016Article
- Article
- Vibration of the organ of Corti within the cochlear apex in mice.Journal of neurophysiology · 2014Article
- The physiology of mechanoelectrical transduction channels in hearing.Physiological reviews · 2014Review
- Human fetal inner ear involvement in congenital cytomegalovirus infection.Acta neuropathologica communications · 2013Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The cochlea's high sensitivity stems from the active process of outer hair cells, which possess two force-generating mechanisms: active hair-bundle motility elicited by Ca(2+) influx and somatic motility mediated by the voltage-sensitive protein prestin. Although interference with prestin has demonstrated a role for somatic motility in the active process, it remains unclear whether hair-bundle motility contributes in vivo. We selectively perturbed the two mechanisms by infusing substances into the endolymph or perilymph of the chinchilla's cochlea and then used scanning laser interferometry to measure vibrations of the basilar membrane. Blocking somatic motility, damaging the tip links of hair bundles, or depolarizing hair cells eliminated amplification. While reducing amplification to a lesser degree, pharmacological perturbation of active hair-bundle motility diminished or eliminated the nonlinear compression underlying the broad dynamic range associated with normal hearing. The results suggest that active hair-bundle motility plays a significant role in the amplification and compressive nonlinearity of the cochlea.
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