ArticleProceedings of the National Academy of Sciences of the United States of America2012
Dendritic upconverting nanoparticles enable in vivo multiphoton microscopy with low-power continuous wave sources.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Unlocking Multimodal Nonlinear Microscopy for Deep-Tissue Imaging under Continuous-Wave Excitation with Tunable Upconverting Nanoparticles.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Molecular near-infrared triplet-triplet annihilation upconversion with eigen oxygen immunity.Nature communications · 2024Article
- Bioimaging with Upconversion Nanoparticles.Advanced photonics research · 2022Article
- True FRET-based sensing of pH via Separation of FRET and Photon Reabsorption.Advanced optical materials · 2022Article
- Review
- In vivo deep-tissue microscopy with UCNP/Janus-dendrimers as imaging probes: resolution at depth and feasibility of ratiometric sensing.Nanoscale · 2020Article
- Prospects for the Use of Upconverting Nanoparticles as a Contrast Agent for Enumeration of Circulating Cells in vivo.International journal of nanomedicine · 2020Article
- Self-assembled pearl-necklace patterned upconverting nanocrystals with highly efficient blue and ultraviolet emission: femtosecond laser based upconversion properties.RSC advances · 2019Article
- Optical Detection of Intracellular Quantities Using Nanoscale Technologies.Accounts of chemical research · 2019Article
- Photostable and efficient upconverting nanocrystal-based chemical sensors.Optical Materials · 2018Article
- Current Advances in Lanthanide-Doped Upconversion Nanostructures for Detection and Bioapplication.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2016Article
- Engineering nanomaterials to address cell-mediated inflammation in atherosclerosis.Regenerative engineering and translational medicine · 2016Article
- Near-infrared light activated delivery platform for cancer therapy.Advances in colloid and interface science · 2015Review
- Long-wavelength analyte-sensitive luminescent probes and optical (bio)sensors.Methods and applications in fluorescence · 2015Article
- Upconversion nanoparticles: a versatile solution to multiscale biological imaging.Bioconjugate chemistry · 2015Review
- Upconversion nanoparticles: design, nanochemistry, and applications in theranostics.Chemical reviews · 2014Review
- Imaging macrophages with nanoparticles.Nature materials · 2014Review
- Lanthanide nano-drums: a new class of molecular nanoparticles for potential biomedical applications.Faraday discussions · 2014Article
- Low power upconverted near-IR light for efficient polymeric nanoparticle degradation and cargo release.Advanced materials (Deerfield Beach, Fla.) · 2013Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
We report a group of optical imaging probes, comprising upconverting lanthanide nanoparticles (UCNPs) and polyanionic dendrimers. Dendrimers with rigid cores and multiple carboxylate groups at the periphery are able to tightly bind to surfaces of UCNPs pretreated with NOBF(4), yielding stable, water-soluble, biocompatible nanomaterials. Unlike conventional linear polymers, dendrimers adhere to UCNPs by donating only a fraction of their peripheral groups to the UCNP-surface interactions. The remaining termini make up an interface between the nanoparticle and the aqueous phase, enhancing solubility and offering multiple possibilities for subsequent modification. Using optical probes as dendrimer cores makes it possible to couple the UCNPs signal to analyte-sensitive detection via UCNP-to-chromophore excitation energy transfer (EET). As an example, we demonstrate that UCNPs modified with porphyrin-dendrimers can operate as upconverting ratiometric pH nanosensors. Dendritic UCNPs possess excellent photostability, solubility, and biocompatibility, which make them directly suitable for in vivo imaging. Polyglutamic dendritic UCNPs injected in the blood of a mouse allowed mapping of the cortical vasculature down to 400 μm under the tissue surface, thus demonstrating feasibility of in vivo high-resolution two-photon microscopy with continuous wave (CW) excitation sources. Dendrimerization as a method of solubilization of UCNPs opens up numerous possibilities for use of these unique agents in biological imaging and sensing.
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