ArticleProceedings of the National Academy of Sciences of the United States of America2012
Motor transport of self-assembled cargos in crowded environments.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Polarity sorting of actin filaments by motor-driven cargo transport.Biophysical journal · 2025Article
- Long-term cargo tracking reveals intricate trafficking through active cytoskeletal networks in the crowded cellular environment.Nature communications · 2023Article
- Trisomy 21 increases microtubules and disrupts centriolar satellite localization.Molecular biology of the cell · 2022Article
- Simulation of receptor triggering by kinetic segregation shows role of oligomers and close contacts.Biophysical journal · 2022Article
- Axonal mRNA translation in neurological disorders.RNA biology · 2021Review
- The crowding dynamics of the motor protein kinesin-II.PloS one · 2020Article
- The ability of the kinesin-2 heterodimer KIF3AC to navigate microtubule networks is provided by the KIF3A motor domain.The Journal of biological chemistry · 2019Article
- Article
- Limited processivity of single motors improves overall transport flux of self-assembled motor-cargo complexes.Physical review. E · 2019Article
- Geometry of antiparallel microtubule bundles regulates relative sliding and stalling by PRC1 and Kif4A.eLife · 2018Article
- Trisomy 21 Represses Cilia Formation and Function.Developmental cell · 2018Article
- A fluid membrane enhances the velocity of cargo transport by small teams of kinesin-1.The Journal of chemical physics · 2018Article
- Cargo crowding at actin-rich regions along axons causes local traffic jams.Traffic (Copenhagen, Denmark) · 2018Article
- She1 affects dynein through direct interactions with the microtubule and the dynein microtubule-binding domain.Nature communications · 2017Article
- Native kinesin-1 does not bind preferentially to GTP-tubulin-rich microtubules in vitro.Cytoskeleton (Hoboken, N.J.) · 2017Article
- KIF5A transports collagen vesicles of myofibroblasts during pleural fibrosis.Scientific reports · 2017Article
- Single Molecule Investigation of Kinesin-1 Motility Using Engineered Microtubule Defects.Scientific reports · 2017Article
- The Dark Matter of Biology.Biophysical journal · 2016Review
- Microtubule Defects Influence Kinesin-Based Transport In Vitro.Biophysical journal · 2016Article
- Kinesin-2 KIF3AC and KIF3AB Can Drive Long-Range Transport along Microtubules.Biophysical journal · 2015Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracellular transport of cargo particles is performed by multiple motors working in concert. However, the mechanism of motor association to cargos is unknown. It is also unknown how long individual motors stay attached, how many are active, and how multimotor cargos would navigate a densely crowded filament with many other motors. Prior theoretical and experimental biophysical model systems of intracellular cargo have assumed fixed teams of motors transporting along bare microtubules or microtubules with fixed obstacles. Here, we investigate a regime of cargos transporting along microtubules crowded with free motors. Furthermore, we use cargos that are able to associate or dissociate motors as it translocates. We perform in vitro motility reconstitution experiments with high-resolution particle tracking. Our model system consists of a quantum dot cargo attached to kinesin motors, and additional free kinesin motors that act as traffic along the microtubule. Although high densities of kinesin motors hinder forward motion, resulting in a lower velocity, the ability to associate motors appears to enhance the run length and attachment time of the quantum dot, improving overall cargo transport. These results suggest that cargos that can associate new motors as they transport could overcome traffic jams.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.