ArticleHypertension (Dallas, Tex. : 1979)2013
Direct evidence for intrarenal chymase-dependent angiotensin II formation on the diabetic renal microvasculature.
Article in Hypertension (Dallas, Tex. : 1979), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Telmisartan reduces systemic inflammation and alters the renin-angiotensin system in mild COVID-19.Scientific reports · 2025Trial
- Mast cell-mediated immune regulation in health and disease.Frontiers in medicine · 2023Review
- Aristolochic Acid Induces Chronic Kidney Disease in ACE Knockout Mice.International journal of preventive medicine · 2021Article
- Mast Cell Chymase and Kidney Disease.International journal of molecular sciences · 2020Review
- The contribution of chymase-dependent formation of ANG II to cardiac dysfunction in metabolic syndrome of young rats: roles of fructose and EETs.American journal of physiology. Heart and circulatory physiology · 2020Article
- Novel Insight into the in vivo Function of Mast Cell Chymase: Lessons from Knockouts and Inhibitors.Journal of innate immunity · 2020Review
- Chymase inhibition retards albuminuria in type 2 diabetes.Physiological reports · 2019Article
- Nicotine and the renin-angiotensin system.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Review
- Detection of chymase activity using a specific peptide probe conjugated onto gold nanoparticles.RSC advances · 2018Article
- Role of the cytochrome P-450/ epoxyeicosatrienoic acids pathway in the pathogenesis of renal dysfunction in cirrhosis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2018Article
- Combination of Chymostatin and Aliskiren attenuates ER stress induced by lipid overload in kidney tubular cells.Lipids in health and disease · 2018Article
- Lack of contribution of nitric oxide synthase to cholinergic vasodilation in murine renal afferent arterioles.American journal of physiology. Renal physiology · 2018Article
- Multifunctional Role of Chymase in Acute and Chronic Tissue Injury and Remodeling.Circulation research · 2018Review
- Plasma and Kidney Angiotensin Peptides: Importance of the Aminopeptidase A/Angiotensin III Axis.American journal of hypertension · 2015Article
- Differential expression of the angiotensin-(1-12)/chymase axis in human atrial tissue.Therapeutic advances in cardiovascular disease · 2015Article
- The compensatory renin-angiotensin system in the central regulation of arterial pressure: new avenues and new challenges.Therapeutic advances in cardiovascular disease · 2015Review
- Classical Renin-Angiotensin system in kidney physiology.Comprehensive Physiology · 2014Review
- Intrarenal renin-angiotensin system in regulation of glomerular function.Current opinion in nephrology and hypertension · 2014Review
- Angiotensin converting enzyme 2: a new important player in the regulation of glycemia.IUBMB life · 2013Review
- Enhanced vascular chymase-dependent conversion of endothelin in the diabetic kidney.Ochsner journal · 2013Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Our previous work supports a major role for angiotensin-converting enzyme (ACE)-independent intrarenal angiotensin (ANG) II formation on microvascular function in type 2 diabetes mellitus. We tested the hypothesis that there is a switch from renal vascular ACE-dependent to chymase-dependent ANGII formation in diabetes mellitus. The in vitro juxtamedullary afferent arteriole (AA) contractile responses to the intrarenal conversion of the ACE-specific, chymase-resistant ANGI peptide ([Pro(10)]ANGI) to ANGII were significantly reduced in kidneys of diabetic (db/db) compared with control (db/m) mice. AA responses to the intrarenal conversion of the chymase-specific, ACE-resistant ANGI peptide ([Pro(11), D-Ala(12)]ANGI) to ANGII were significantly enhanced in kidneys of diabetic compared with control mice. AA diameters were significantly reduced by 9 ± 2, 15 ± 3, and 24 ± 3% of baseline in diabetic kidneys in response to 10, 100, and 1000 nmol/L [Pro(11), D-Ala(12)]ANGI, respectively, and the responses were significantly attenuated by angiotensin type 1 receptor or chymase-specific (JNJ-18054478) inhibition. [Pro(11), D-Ala(12)]ANGI did not produce a significant AA vasoconstriction in control kidneys. Chymase inhibition significantly attenuated ANGI-induced AA vasoconstriction in diabetic, but not control kidneys. Renal vascular mouse mast cell protease-4 or chymase/β-actin mRNA expression was significantly augmented by 5.1 ± 1.4 fold; while ACE/β-actin mRNA expression was significantly attenuated by 0.42 ± 0.08 fold in diabetic compared with control tissues. In summary, intrarenal formation of ANGII occurs primarily via ACE in the control, but via chymase in the diabetic vasculature. In conclusion, chymase-dependent mechanisms may contribute to the progression of diabetic kidney disease.
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