Evidence map›Paper›PMID 23213072›Full record

Trial reportCancer prevention research (Philadelphia, Pa.)2013

Effect of exercise on markers of inflammation in breast cancer survivors: the Yale exercise and survivorship study.

Sara B Jones, Gwendolyn A Thomas, Sara D Hesselsweet, Marty Alvarez-Reeves, Herbert Yu, Melinda L Irwin

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cancer prevention research (Philadelphia, Pa.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05009849 (Randomized Controlled Evaluating the Role of Exercise in Women Undergoing Treatment for Breast Cancer), which is not on this map. Cited by 70 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 16 pooled it
6.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05009849 naactive not recruitingnot on this map

Randomized Controlled Evaluating the Role of Exercise in Women Undergoing Treatment for Breast Cancer

TypeinterventionalSponsorTata Memorial CentreRan2010 to 2030Enrolled850ConditionsBreast Cancer PatientsArmsYoga Exercises
3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 16 syntheses or guidelines pooled it, 122 citations in OpenAlex.

  1. Pooled it
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  8. Exercise Therapy and Radiation Therapy for Cancer: A Systematic Review.International journal of radiation oncology, biology, physics · 2021
    Pooled it
  9. Effects of Diet and Exercise-Induced Weight Loss on Biomarkers of Inflammation in Breast Cancer Survivors: A Systematic Review and Meta-analysis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021
    Pooled it
  10. Body weight management in overweight and obese breast cancer survivors.The Cochrane database of systematic reviews · 2020
    Pooled it
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  15. Physical activity for women with breast cancer after adjuvant therapy.The Cochrane database of systematic reviews · 2018
    Pooled it
  16. Guideline
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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sara B JonesYale School of Public Health, New Haven, CT 06520, USA.
Gwendolyn A Thomas
Sara D Hesselsweet
Marty Alvarez-Reeves
Herbert Yu
Melinda L Irwin
Dana-Farber Cancer Institute · US

Funding

ZIPRASIDONE IN TOURETTES SYNDROME, OBSESSIVE COMPULSIVE &PERVASIVE DEV. DISORDERM01RR000125 · NCRR · YALE UNIVERSITY · PI ALPERN, ROBERT J · 1985 to 2006
$24.1M
Research Training: Self and Family ManagementT32NR008346 · NINR · YALE UNIVERSITY · PI GREY, MARGARET · 2003 to 2018
$4.7M
NCRR NIH HHS M01 RR000125NCRR NIH HHS M01-RR00125NINR NIH HHS T32 NR008346
6 · The paper itself

Abstract

Physical activity is associated with improved breast cancer survival, but the underlying mechanisms, possibly including modification of the inflammatory state, are not well understood. We analyzed changes in interleukin (IL)-6, C-reactive protein (CRP), and TNF-α in a randomized controlled trial of exercise in postmenopausal breast cancer survivors. Seventy-five women, recruited through the Yale-New Haven Hospital Tumor Registry, were randomized to either a six-month aerobic exercise intervention or usual care. Correlations were calculated between baseline cytokines, adiposity, and physical activity measures. Generalized linear models were used to assess the effect of exercise on IL-6, CRP, and TNF-α. At baseline, IL-6 and CRP were positively correlated with body fat and body mass index (BMI) and were inversely correlated with daily pedometer steps (P < 0.001). We found no significant effect of exercise on changes in inflammatory marker concentrations between women randomized to exercise versus usual care, though secondary analyses revealed a significant reduction in IL-6 among exercisers who reached 80% of the intervention goal compared with those who did not. Future studies should examine the effect of different types and doses of exercise and weight loss on inflammatory markers in large-scale trials of women diagnosed with breast cancer.

Indexed as

AdultAgedBiomarkersBreast NeoplasmsCarcinomaC-Reactive ProteinExerciseFemaleHumansInflammationInterleukin-6Middle AgedSurvival RateSurvivorsTumor Necrosis Factor-alphaBiomarkersC-Reactive ProteinInterleukin-6Tumor Necrosis Factor-alpha

Identifiers

PMID23213072
PMCPMC3839104
OpenAlexW2052254431

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.