Evidence map›Paper›PMID 23213025›Full record

ReviewHepatology (Baltimore, Md.)2013

Hepatoprotective and antiviral functions of silymarin components in hepatitis C virus infection.

Stephen J Polyak, Peter Ferenci, Jean-Michel Pawlotsky

Abstract readReview
In one paragraph

Review in Hepatology (Baltimore, Md.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Preparation of silibinin- dendrimer-stabilized Au nanoparticles for decreasing vancomycin resistance in S. aureus clinical isolates.International microbiology : the official journal of the Spanish Society for Microbiology · 2026
    Article
  4. Review
  5. Sumac Polyphenols as Pan-Herpesvirus Inhibitors.International journal of molecular sciences · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Effects ofMolecules (Basel, Switzerland) · 2023
    Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Changes in Glutathione Content in Liver Diseases: An Update.Antioxidants (Basel, Switzerland) · 2021
    Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Stephen J PolyakDepartment of Laboratory Medicine, University of Washington, Seattle, WA 98104, USA. polyak@uw.edu
Peter Ferenci
Jean-Michel Pawlotsky

Funding

Suppression of HCV-specific CD4+ T Cells by Core ProteinU19AI066328 · NIAID · UNIVERSITY OF COLORADO DENVER · PI ROSEN, HUGO RAMON · 2005 to 2014
$6.8M
Mechanisms of Silymarin HepatoprotectionR01AT006842 · NCCIH · UNIVERSITY OF WASHINGTON · PI POLYAK, STEPHEN J. · 2011 to 2015
$2.7M
HCV-Host Interactions During Antiviral TherapyR56AI091840 · NIAID · UNIVERSITY OF WASHINGTON · PI POLYAK, STEPHEN J. · 2011 to 2011
$251k
NCCIH NIH HHS R01 AT006842NCCIH NIH HHS R01AT006842NIAID NIH HHS R56 AI091840NIAID NIH HHS R56AI091840NIAID NIH HHS U19 AI066328NIAID NIH HHS U19AI066328
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAntiviral AgentsFatty LiverHepatitis C, ChronicHumansNon-alcoholic Fatty Liver DiseaseProtective AgentsSilymarinAntiviral AgentsProtective AgentsSilymarin

Identifiers

PMID23213025
PMCPMC3594650

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.