Evidence map›Paper›PMID 23212881›Full record

ArticleBMJ (Clinical research ed.)2012

Short term outcomes after extreme preterm birth in England: comparison of two birth cohorts in 1995 and 2006 (the EPICure studies).

Kate L Costeloe, Enid M Hennessy, Sadia Haider, Fiona Stacey, Neil Marlow, Elizabeth S Draper

2 registry-linked trialsAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ (Clinical research ed.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 262 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
262citing papers in PubMed, 15 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02692820 nacompletednot on this mapstarted 2016, after this paper: background citation

Preventing Preterm Birth With Probiotics - Pilot Randomised Trial

TypeinterventionalSponsorQueen Mary University of LondonRan2016 to 2017Enrolled304ConditionsPreterm BirthArmsProbiotic, Placebo Comparator
NCT05328817 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Azithromycin Versus Erythromycin For Preterm Prelabor Rupture of Membranes: A Randomized Controlled Trial

TypeinterventionalSponsorEastern Virginia Medical SchoolRan2022 to 2025Enrolled240ConditionsPreterm Premature Rupture of MembraneArmsAntibiotics
3 · Its place in the literature

Who cites it

262 citing papers in PubMed, 15 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Singapore Neonatal Resuscitation Guidelines 2016.Singapore medical journal · 2017
    Guideline
  15. Pooled it
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Trial

202 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Kate L CosteloeCentre For Paediatrics, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK. k.l.costeloe@qmul.ac.uk
Enid M Hennessy
Sadia Haider
Fiona Stacey
Neil Marlow
Elizabeth S Draper

Funding

Medical Research Council G0401525
6 · The paper itself

Abstract

objectiveTo determine survival and neonatal morbidity for babies born between 22 and 26 weeks' gestation in England during 2006, and to evaluate changes in outcome since 1995 for babies born between 22 and 25 weeks' gestation.

designProspective national cohort studies.

settingMaternity and neonatal units in England.

participants3133 births between 22 and 26 weeks' gestation in 2006; 666 admissions to neonatal units in 1995 and 1115 in 2006 of babies born between 22 and 25 weeks' gestation.

main outcome measuresSurvival to discharge from hospital, pregnancy and delivery outcomes, infant morbidity until discharge.

resultsIn 2006, survival of live born babies was 2% (n=3) for those born at 22 weeks' gestation, 19% (n=66) at 23 weeks, 40% (n=178) at 24 weeks, 66% (n=346) at 25 weeks, and 77% (n=448) at 26 weeks (P<0.001). At discharge from hospital, 68% (n=705) of survivors had bronchopulmonary dysplasia (receiving supplemental oxygen at 36 weeks postmenstrual age), 13% (n=135) had evidence of serious abnormality on cerebral ultrasonography, and 16% (n=166) had laser treatment for retinopathy of prematurity. For babies born between 22 and 25 weeks' gestation from March to December, the number of admissions for neonatal care increased by 44%, from 666 in 1995 to 959 in 2006. By 2006 adherence to evidence based practice associated with improved outcome had significantly increased. Survival increased from 40% to 53% (P<0.001) overall and at each week of gestation: by 9.5% (confidence interval -0.1% to 19%) at 23 weeks, 12% (4% to 20%) at 24 weeks, and 16% (9% to 23%) at 25 weeks. The proportions of babies surviving in 2006 with bronchopulmonary dysplasia, major cerebral scan abnormality, or weight and/or head circumference <-2 SD were similar to those in 1995, but the proportion treated for retinopathy of prematurity had increased from 13% to 22% (P=0.006). Predictors of mortality and morbidity were similar in both cohorts.

conclusionSurvival of babies born between 22 and 25 weeks' gestation has increased since 1995 but the pattern of major neonatal morbidity and the proportion of survivors affected are unchanged. These observations reflect an important increase in the number of preterm survivors at risk of later health problems.

Indexed as

Infant, Extremely PrematureCohort StudiesEnglandFemaleGestational AgeGuideline AdherenceHumansInfant MortalityInfant, NewbornInfant, Premature, DiseasesIntensive Care, NeonatalKaplan-Meier EstimateLinear ModelsLogistic ModelsMaleObstetric Labor Complications

Identifiers

PMID23212881
PMCPMC3514472

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.