Trial reportJournal of neuro-oncology2013
Enhancing quality of life and mastery of informal caregivers of high-grade glioma patients: a randomized controlled trial.
Trial report in Journal of neuro-oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 7 syntheses or guidelines pooled it, 114 citations in OpenAlex.
- Interventions to improve outcomes for caregivers of patients with advanced cancer: a meta-analysis.Journal of the National Cancer Institute · 2023Pooled it
- Effectiveness of Skill-Building Interventions for Informal Caregivers of Adults with Cancer: a Systematic Review.Journal of cancer education : the official journal of the American Association for Cancer Education · 2023Pooled it
- Benefits of supportive strategies for carers of people with high-grade glioma: a systematic review : Strategies for addressing the needs of high-grade glioma carers.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Pooled it
- Early palliative interventions for improving outcomes in people with a primary malignant brain tumour and their carers.The Cochrane database of systematic reviews · 2022Pooled it
- Interventions to help support caregivers of people with a brain or spinal cord tumour.The Cochrane database of systematic reviews · 2019Pooled it
- Psychosocial interventions for informal caregivers of people living with cancer.The Cochrane database of systematic reviews · 2019Pooled it
- Controlled rehabilitative and supportive care intervention trials in patients with high-grade gliomas and their caregivers: a systematic review.BMJ supportive & palliative care · 2016Pooled it
- The Effect on Quality of Life after Three-Dimensional Intensity-Modulated Radiation Therapy in Patients with Low-Grade Glioma.Computational and mathematical methods in medicine · 2022Trial
- The Effectiveness of a Dyadic Pain Management Program for Community-Dwelling Older Adults with Chronic Pain: A Pilot Randomized Controlled Trial.International journal of environmental research and public health · 2020Trial
- Online Couple-Based Meditation Intervention for Patients With Primary or Metastatic Brain Tumors and Their Partners: Results of a Pilot Randomized Controlled Trial.Journal of pain and symptom management · 2020Trial
- Feasibility Testing and Refinement of a Supportive Educational Intervention for Carers of Patients with High-Grade Glioma - a Pilot Study.Journal of cancer education : the official journal of the American Association for Cancer Education · 2018Trial
- Exploring the cancer caregiver's journey through web-based Meaning-Centered Psychotherapy.Psycho-oncology · 2018Trial
- Trial
- The Added Value of Family Caregivers' Level of Mastery in Predicting Survival of Glioblastoma Patients: A Validation Study.Cancer nursingTrial
- Coping with primary brain tumors together: a scoping review of dyadic psychosocial interventions.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Group-based interventions for caregivers to patients diagnosed with a brain tumor: A systematic review.Neuro-oncology practice · 2025Article
- The communication of a high-grade glioma diagnosis- patients' reflections and perspectives based on a study-specific questionnaire.Journal of neuro-oncology · 2025Article
- Reporting standards in randomized controlled trials involving neuro-oncology caregivers: A systematic review report from the RANO-Cares working group.Neuro-oncology practice · 2025Article
- Health-Related Quality of Life and Treatment Satisfaction of Patients with Malignant IDH Wild-Type Gliomas and Their Caregivers.Current oncology (Toronto, Ont.) · 2024Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-grade gliomas (HGG) are serious primary brain tumors that may prevent the patient from functioning normally in social, emotional and cognitive respect. Often the partner's role will convert to that of informal caregiver. Consequently, they may experience significant stress and reductions in caregiver mastery, negatively affecting their health-related quality of life (HRQOL). We aimed at (1) determining factors that impact HRQOL and mastery of caregivers of HGG patients, and (2) investigate if a structured intervention consisting of psychoeducation and cognitive behavioral therapy leads to improvements in the mental component of HRQOL and mastery of caregivers. Fifty-six patient-caregiver dyads were randomly assigned to the intervention group or the care as usual group. The intervention program consisted of six one-hour sessions with a psychologist. Participants completed questionnaires concerning their perceptions of the patients' HRQOL (SF-36), neurological functioning (BN20), and cognitive functioning (MOS), and concerning their own HRQOL (SF-36) and feelings of caregiver mastery (CMS) both at baseline (i.e. before randomization) and every 2 months thereafter until 8 months later, five times in total. Patients' HRQOL and neurological functioning were found to be related to HRQOL and feelings of mastery of the informal caregiver at baseline. The intervention helped caregivers in maintaining a stable level of HRQOL and improved feelings of mastery over an 8 month period. Our findings suggest that informal caregivers can benefit from a psychological intervention as it is a helpful tool in maintaining a stable level of mental functioning and caregiver mastery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.