Evidence map›Paper›PMID 23212475›Full record

ReviewNature reviews. Molecular cell biology2013

New insights into the regulation and cellular functions of the ARP2/3 complex.

Jeremy D Rotty, Congying Wu, James E Bear

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Molecular cell biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 316 papers.

0numbers the graph read from it
0cells of the map it votes in
316citing papers in PubMed
16.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

316 citing papers in PubMed, 499 citations in OpenAlex.

  1. Article
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  3. β-strand addition within tip initiation complexes licenses assembly of diverse type IV filaments.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  13. Control of microglial dynamics by the Arp2/3 complex and the autism- and schizophrenia-associated protein CYFIP1.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  14. Article
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  17. Article
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  19. Review
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256 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Jeremy D RottyUNC Lineberger Comprehensive Cancer Center, Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA.
Congying Wu
James E Bear
University of North Carolina at Chapel Hill · USUNC Lineberger Comprehensive Cancer Center

Funding

The Coordination of Cytoskeletal Dynamics by CoroninsR01GM083035 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BEAR, JAMES E · 2007 to 2011
$1.2M
Howard Hughes Medical InstituteNIGMS NIH HHS GM083035
6 · The paper itself

Abstract

The actin-related protein 2/3 (ARP2/3) complex nucleates branched actin filament networks, but requires nucleation promoting factors (NPFs) to stimulate this activity. NPFs include proteins such as Wiskott-Aldrich syndrome protein (WASP), neural WASP (NWASP), WASP family verprolin-homologous protein (WAVE; also known as SCAR) and the recently identified WASP and SCAR homologue (WASH) complex. The mechanisms underlying NPF-dependent regulation and the cellular functions of ARP2/3 are being unravelled using new chemical and genetic approaches. Of particular interest is the role of the ARP2/3 complex in vesicular trafficking and directional cell motility.

Indexed as

Actin-Related Protein 2-3 ComplexCell MovementCytoskeletal ProteinsHumansMicrofilament ProteinsProtein ConformationProtein TransportWiskott-Aldrich Syndrome ProteinWiskott-Aldrich Syndrome Protein FamilyWiskott-Aldrich Syndrome Protein, NeuronalActin-Related Protein 2-3 ComplexCytoskeletal ProteinsMicrofilament ProteinsWASF1 protein, humanWASH protein, humanWiskott-Aldrich Syndrome ProteinWiskott-Aldrich Syndrome Protein FamilyWiskott-Aldrich Syndrome Protein, Neuronal

Identifiers

PMID23212475
OpenAlexW2076123445

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.