ArticleMolecular and cellular biochemistry2013
Alcohol-induced oxidative/nitrosative stress alters brain mitochondrial membrane properties.
Article in Molecular and cellular biochemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- Biochemical neuroplasticity in the cerebellum after physical exercise: Systematic review and meta-analysis.PloS one · 2025Pooled it
- Unraveling the Time-Dependent Effects of Ethanol on Liver Disease: Insights From a Mice Model.Biotechnology and applied biochemistry · 2026Article
- AlteredeNeuro · 2026Article
- Recreational substance use and aneurysmal subarachnoid hemorrhage: differential effects of alcohol and THC.Neurosurgical review · 2026Article
- Glymphatic system dysfunction in alcohol use disorder: Current understanding and future directions.World journal of psychiatry · 2025Review
- Methylsulfonylmethane Mitigates Neurobehavioral Impairment, Oxidative Stress, Changes in Trace Elements and Clock Expression in Alcohol and Circadian-Disrupted C57BL/6J Mice Brain.Neurochemical research · 2025Article
- Mitoquinol improves phagocytosis and glycolysis in ethanol-exposed macrophages via HIF-1α-PFKP axis.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- The Optic Nerve at Stake: Update on Environmental Factors Modulating Expression of Leber's Hereditary Optic Neuropathy.Biomedicines · 2024Review
- The Influence of Arsenic Co-Exposure in a Model of Alcohol-Induced Neurodegeneration in C57BL/6J Mice.Brain sciences · 2023Article
- Adaptor protein complex 2 in the orbitofrontal cortex predicts alcohol use disorder.Molecular psychiatry · 2023Article
- The Hypothalamic-Pituitary-Gonadal Axis in Men with Schizophrenia.International journal of molecular sciences · 2023Review
- Untargeted and Targeted Blood Lipidomic Signature Profile of Gestational Alcohol Exposure.Nutrients · 2023Article
- Neuroprotective Effect of Piclamilast-Induced Post-Ischemia Pharmacological Treatment in Mice.Neurochemical research · 2022Article
- Synthesis, In Silico and Pharmacological Evaluation of New Thiazolidine-4-Carboxylic Acid Derivatives Against Ethanol-Induced Neurodegeneration and Memory Impairment.Journal of inflammation research · 2022Article
- Nutrients to Improve Mitochondrial Function to Reduce Brain Energy Deficit and Oxidative Stress in Migraine.Nutrients · 2021Review
- Alcohol exposure increases manganese accumulation in the brain and exacerbates manganese-induced neurotoxicity in mice.Archives of toxicology · 2021Article
- Age-Related Features of the Viscosity of Plasma and Mitochondrial Membranes of Hepatocytes in Liver Cirrhosis.Bulletin of experimental biology and medicine · 2021Article
- Alcohol induces mitochondrial derangements in alveolar macrophages by upregulating NADPH oxidase 4.Alcohol (Fayetteville, N.Y.) · 2021Article
- Chronic Low-Dose Alcohol Consumption Promotes Cerebral Angiogenesis in Mice.Frontiers in cardiovascular medicine · 2021Article
- Alcohol-Induced Neuroinflammatory Response and Mitochondrial Dysfunction on Aging and Alzheimer's Disease.Frontiers in behavioral neuroscience · 2021Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic alcohol consumption causes numerous biochemical and biophysical changes in the central nervous system, in which mitochondria is the primary organelle affected. In the present study, we hypothesized that alcohol alters the mitochondrial membrane properties and leads to mitochondrial dysfunction via mitochondrial reactive oxygen species (mROS) and reactive nitrogen species (RNS). Alcohol-induced hypoxia further enhances these effects. Administration of alcohol to rats significantly increased the mitochondrial lipid peroxidation and protein oxidation with decreased SOD2 mRNA and protein expression was decreased, while nitric oxide (NO) levels and expression of iNOS and nNOS in brain cortex were increased. In addition, alcohol augmented HIF-1α mRNA and protein expression in the brain cortex. Results from this study showed that alcohol administration to rats decreased mitochondrial complex I, III, IV activities, Na(+)/K(+)-ATPase activity and cardiolipin content with increased anisotropic value. Cardiolipin regulates numerous enzyme activities, especially those related to oxidative phosphorylation and coupled respiration. In the present study, decreased cardiolipin could be ascribed to ROS/RNS-induced damage. In conclusion, alcohol-induced ROS/RNS is responsible for the altered mitochondrial membrane properties, and alcohol-induced hypoxia further enhance these alterations, which ultimately leads to mitochondrial dysfunction.
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