ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2013
Microarray-based analysis of gene regulation by transcription factors and microRNAs in glioma.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Prognostic Significance of MicroRNAs in Glioma: A Systematic Review and Meta-Analysis.BioMed research international · 2019Pooled it
- Identification of potential crucial genes and mechanisms associated with metabolically unhealthy obesity based on the gene expression profile.Frontiers in genetics · 2025Article
- Micro RNAs as a Diagnostic Marker between Glioma and Primary CNS Lymphoma: A Systematic Review.Cancers · 2023Review
- Construction of a potential microRNA, transcription factor and mRNA regulatory network in hepatocellular carcinoma.Translational cancer research · 2020Article
- Comprehensive analysis of a long non-coding RNA-mediated competitive endogenous RNA network in glioblastoma multiforme.Experimental and therapeutic medicine · 2019Article
- Juglone reduces growth and migration of U251 glioblastoma cells and disrupts angiogenesis.Oncology reports · 2017Article
- Sparse feature selection for classification and prediction of metastasis in endometrial cancer.BMC genomics · 2017Article
- Network and pathway analysis of microRNAs, transcription factors, target genes and host genes in human glioma.Oncology letters · 2016Article
- Methylation of the miR-126 gene associated with glioma progression.Familial cancer · 2016Article
- Role of MicroRNAs in Malignant Glioma.Chinese medical journal · 2015Review
- Kruppel-Like Factor 2-Mediated Suppression of MicroRNA-155 Reduces the Proinflammatory Activation of Macrophages.PloS one · 2015Article
- Reduced levels of microRNAs miR-124a and miR-150 are associated with increased proinflammatory mediator expression in Krüppel-like factor 2 (KLF2)-deficient macrophages.The Journal of biological chemistry · 2014Article
- Overexpression of microRNA-155 predicts poor prognosis in glioma patients.Medical oncology (Northwood, London, England) · 2014Article
- miR-125b inhibits Connexin43 and promotes glioma growth.Cellular and molecular neurobiology · 2013Article
- MicroRNA and transcription factor mediated regulatory network for ovarian cancer: regulatory network of ovarian cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Article
- A promising light for an impossible disease: miRNAs in malignant gliomas.CNS oncology · 2013Article
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Transcription factor (TF) and microRNA (miRNA) are two best characterized gene regulators that have been found to play an important role in gene regulation. However, high throughput screening the interaction relationships between transcription factors, microRNAs, and target genes in gliomas remains rare. Using GSE16666 and GSE13091 datasets downloaded from Gene Expression Omnibus data, we first screened the differentially expressed genes in gliomas. We explored the regulation relationship among TFs, miRNAs and target genes by different algorithms. The underlying molecular mechanisms of these crucial target genes were investigated by Gene Ontology function and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis. Our study has developed three regulation relationships between two TFs and three miRNAs, including TP53/hsa-mir-155, TP53/hsa-mir-125b, and KLF2/hsa-mir-126. In addition, we also constructed a regulation network of the target genes by transcription factors and miRNAs. Some of them had been demonstrated to be involved in glioma progression via various pathways. For example, ATP2B2 target gene could be regulated by has-mir-181a to involve in calcium signaling pathway. RB1 could be regulated by has-miR-26a to participate in pathways in cancer. Smad7 could be regulated by has-miR-21 via intracellular TGF-β signal transduction. We constructed a comprehensive regulatory network which was found to play an important role in gliomas progression.
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