ArticleNature communications2012
An RNA architectural locus control region involved in Dscam mutually exclusive splicing.
Article in Nature communications, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Regulatory paradigm of Dscam1 stochastic alternative splicing through conserved long-range RNA structures.Nucleic acids research · 2026Article
- Ancestral intronic splicing regulatory elements in the SCNbioRxiv : the preprint server for biology · 2026Article
- Current insights into insect immune memory.eLife · 2025Review
- Hidden RNA pairings counteract the "first-come, first-served" splicing principle to drive stochastic choice inScience advances · 2022Article
- May the Odds Be Ever in Your Favor: Non-deterministic Mechanisms Diversifying Cell Surface Molecule Expression.Frontiers in cell and developmental biology · 2021Review
- Complex RNA Secondary Structures Mediate Mutually Exclusive Splicing of ColeopteraFrontiers in genetics · 2021Article
- RNA secondary structures inRNA (New York, N.Y.) · 2020Article
- Revisiting Dscam diversity: lessons from clustered protocadherins.Cellular and molecular life sciences : CMLS · 2019Review
- Competing RNA pairings in complex alternative splicing of a 3' variable region.RNA (New York, N.Y.) · 2018Article
- Article
- Review
- The determinants of alternative RNA splicing in human cells.Molecular genetics and genomics : MGG · 2017Review
- Role and convergent evolution of competing RNA secondary structures in mutually exclusive splicing.RNA biology · 2017Article
- Functional impact of splice isoform diversity in individual cells.Biochemical Society transactions · 2016Review
- Long-range RNA pairings contribute to mutually exclusive splicing.RNA (New York, N.Y.) · 2016Article
- Improvement of Dscam homophilic binding affinity throughout Drosophila evolution.BMC evolutionary biology · 2014Article
- A day in the life of the spliceosome.Nature reviews. Molecular cell biology · 2014Review
- Regulation of Dscam exon 17 alternative splicing by steric hindrance in combination with RNA secondary structures.RNA biology · 2013Article
- Shark IgW C region diversification through RNA processing and isotype switching.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Ultra-deep profiling of alternatively spliced Drosophila Dscam isoforms by circularization-assisted multi-segment sequencing.The EMBO journal · 2013Article
Corrections and comments
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Authors and funding
16 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The most striking example of alternative splicing in a Drosophila melanogaster gene is observed in the Down syndrome cell adhesion molecule, which can generate 38,016 different isoforms. RNA secondary structures are thought to direct the mutually exclusive splicing of Down syndrome cell adhesion molecule, but the underlying mechanisms are poorly understood. Here we describe a locus control region that can activate the exon 6 cluster and specifically allow for the selection of only one exon variant in combination with docking site selector sequence interactions. Combining comparative genomic studies of 63 species with mutational analysis reveals that intricate, tandem multi-'subunit' RNA structures within the locus control region activate species-appropriate alternative variants. Importantly, strengthening the weak splice sites of the target exon can remove the locus control region dependence. Our findings not only provide a locus control region-dependent mechanism for mutually exclusive splicing, but also suggest a model for the evolution of increased complexity in a long-range RNA molecular machine.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.