ArticleThe American journal of psychiatry2012
Genome-wide association study of clinical dimensions of schizophrenia: polygenic effect on disorganized symptoms.
Article in The American journal of psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.
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Who cites it
57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 131 citations in OpenAlex.
- Association of Methylation Signals With Incident Coronary Heart Disease in an Epigenome-Wide Assessment of Circulating Tumor Necrosis Factor α.JAMA cardiology · 2018Pooled it
- Meta-analysis of Positive and Negative Symptoms Reveals Schizophrenia Modifier Genes.Schizophrenia bulletin · 2016Pooled it
- Concordance of positive, negative and disorganised psychotic syndromes in five twin samples.BJPsych open · 2026Article
- Glutamate, Contextual Insensitivity, and Disorganized Speech in First-Episode Schizophrenia: A 7T Magnetic Resonance Spectroscopy Study.Biological psychiatry global open science · 2025Article
- Associations between psychotic experience dimensions and polygenic liability to schizophrenia in a longitudinal birth cohort.BJPsych open · 2025Article
- Polygenic risk for schizophrenia and subjective well-being in a general population sample.Psychological medicine · 2025Article
- Associations of psychotic symptom dimensions with clinical and developmental variables in twin and general clinical samples.The British journal of psychiatry : the journal of mental science · 2025Article
- Disorganized Communication and Social Dysfunction in Schizophrenia: Emerging Concepts and Methods.Current psychiatry reports · 2023Review
- Genomic findings in schizophrenia and their implications.Molecular psychiatry · 2023Review
- Six-year trajectories and associated factors of positive and negative symptoms in schizophrenia patients, siblings, and controls: Genetic Risk and Outcome of Psychosis (GROUP) study.Scientific reports · 2023Article
- Associations Between Cannabis Use, Polygenic Liability for Schizophrenia, and Cannabis-related Experiences in a Sample of Cannabis Users.Schizophrenia bulletin · 2023Article
- Potential diagnostic biomarkers for schizophrenia.Medical review (2021) · 2022Review
- Association of g-quadruplex variants with schizophrenia symptoms.Schizophrenia research · 2022Article
- The Latent Structure of Negative Symptoms in the General Population in Adolescence and Emerging Adulthood.Schizophrenia bulletin open · 2022Article
- Associations between patterns in comorbid diagnostic trajectories of individuals with schizophrenia and etiological factors.Nature communications · 2021Article
- Duration of Untreated Psychosis in First-Episode Psychosis is not Associated With Common Genetic Variants for Major Psychiatric Conditions: Results From the Multi-Center EU-GEI Study.Schizophrenia bulletin · 2021Article
- Prenatal risk factors and neonatal DNA methylation in very preterm infants.Clinical epigenetics · 2021Article
- A genome-wide association study of interhemispheric theta EEG coherence: implications for neural connectivity and alcohol use behavior.Molecular psychiatry · 2021Article
- The continuity of effect of schizophrenia polygenic risk score and patterns of cannabis use on transdiagnostic symptom dimensions at first-episode psychosis: findings from the EU-GEI study.Translational psychiatry · 2021Article
- Evidence of an interaction betweenEuropean psychiatry : the journal of the Association of European Psychiatrists · 2021Article
Corrections and comments
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Authors and funding
24 authors at 1 institution in 1 country.
Funding
Abstract
objectiveMultiple sources of evidence suggest that genetic factors influence variation in clinical features of schizophrenia. The authors present the first genome-wide association study (GWAS) of dimensional symptom scores among individuals with schizophrenia.
methodBased on the Lifetime Dimensions of Psychosis Scale ratings of 2,454 case subjects of European ancestry from the Molecular Genetics of Schizophrenia (MGS) sample, three symptom factors (positive, negative/disorganized, and mood) were identified with exploratory factor analysis. Quantitative scores for each factor from a confirmatory factor analysis were analyzed for association with 696,491 single-nucleotide polymorphisms (SNPs) using linear regression, with correction for age, sex, clinical site, and ancestry. Polygenic score analysis was carried out to determine whether case and comparison subjects in 16 Psychiatric GWAS Consortium (PGC) schizophrenia samples (excluding MGS samples) differed in scores computed by weighting their genotypes by MGS association test results for each symptom factor.
resultsNo genome-wide significant associations were observed between SNPs and factor scores. Most of the SNPs producing the strongest evidence for association were in or near genes involved in neurodevelopment, neuroprotection, or neurotransmission, including genes playing a role in Mendelian CNS diseases, but no statistically significant effect was observed for any defined gene pathway. Finally, polygenic scores based on MGS GWAS results for the negative/disorganized factor were significantly different between case and comparison subjects in the PGC data set; for MGS subjects, negative/disorganized factor scores were correlated with polygenic scores generated using case-control GWAS results from the other PGC samples.
conclusionsThe polygenic signal that has been observed in cross-sample analyses of schizophrenia GWAS data sets could be in part related to genetic effects on negative and disorganized symptoms (i.e., core features of chronic schizophrenia).
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