ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2013
Spontaneous calcium waves in Bergman glia increase with age and hypoxia and may reduce tissue oxygen.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 50 citations in OpenAlex.
- Astrocytes: Orchestrators of brain gas exchange and oxygen homeostasis.The Journal of physiology · 2026Review
- Cortical OProceedings of the National Academy of Sciences of the United States of America · 2026Article
- The vascular contribution to cognitive decline in ageing and dementia.Nature reviews. Neuroscience · 2025Review
- Glial Cells and Aging: From the CNS to the Cerebellum.International journal of molecular sciences · 2025Review
- Oxygen imaging of hypoxic pockets in the mouse cerebral cortex.Science (New York, N.Y.) · 2024Article
- Aging, Neurodegenerative Disorders, and Cerebellum.International journal of molecular sciences · 2024Review
- Astrocytes in human central nervous system diseases: a frontier for new therapies.Signal transduction and targeted therapy · 2023Review
- Astrocytes exhibit diverse CaFrontiers in aging neuroscience · 2022Article
- Calcium Signaling in the Cerebellar Radial Glia and Its Association with Morphological Changes during Zebrafish Development.International journal of molecular sciences · 2021Article
- Age-related alterations in the cerebrovasculature affect neurovascular coupling and BOLD fMRI responses: Insights from animal models of aging.Psychophysiology · 2021Article
- Article
- Astroglial asthenia and loss of function, rather than reactivity, contribute to the ageing of the brain.Pflugers Archiv : European journal of physiology · 2021Review
- Modeling of Astrocyte Networks: Toward Realistic Topology and Dynamics.Frontiers in cellular neuroscience · 2021Article
- Activation of microglia and astrocytes: a roadway to neuroinflammation and Alzheimer's disease.Inflammopharmacology · 2019Review
- Contributions of the glycocalyx, endothelium, and extravascular compartment to the blood-brain barrier.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Role of Purinergic Receptor P2Y1 in Spatiotemporal CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Physiology of Astroglia.Physiological reviews · 2018Review
- Impaired neurovascular coupling in aging and Alzheimer's disease: Contribution of astrocyte dysfunction and endothelial impairment to cognitive decline.Experimental gerontology · 2017Review
- Functional vascular contributions to cognitive impairment and dementia: mechanisms and consequences of cerebral autoregulatory dysfunction, endothelial impairment, and neurovascular uncoupling in aging.American journal of physiology. Heart and circulatory physiology · 2017Review
- The roadmap for estimation of cell-type-specific neuronal activity from non-invasive measurements.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
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4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glial calcium (Ca(2+)) waves constitute a means to spread signals between glial cells and to neighboring neurons and blood vessels. These waves occur spontaneously in Bergmann glia (BG) of the mouse cerebellar cortex in vivo. Here, we tested three hypotheses: (1) aging and reduced blood oxygen saturation alters wave activity; (2) glial Ca(2+) waves change cerebral oxygen metabolism; and (3) neuronal and glial wave activity is correlated. We used two-photon microscopy in the cerebellar cortexes of adult (8- to 15-week-old) and aging (48- to 80-week-old) ketamine-anesthetized mice after bolus loading with OGB-1/AM and SR101. We report that the occurrence of spontaneous waves is 20 times more frequent in the cerebellar cortex of aging as compared with adult mice, which correlated with a reduction in resting brain oxygen tension. In adult mice, spontaneous glial wave activity increased on reducing resting brain oxygen tension, and ATP-evoked glial waves reduced the tissue O(2) tension. Finally, although spontaneous Purkinje cell (PC) activity was not associated with increased glia wave activity, spontaneous glial waves did affect intracellular Ca(2+) activity in PCs. The increased wave activity during aging, as well as low resting brain oxygen tension, suggests a relationship between glial waves, brain energy homeostasis, and pathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.