ArticleEpidemiology and infection2013
Simultaneous detection of viral and bacterial enteric pathogens using the Seeplex® Diarrhea ACE detection system.
Article in Epidemiology and infection, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Systematic review of point-of-need molecular diagnostics for rotavirus and enteric adenoviruses F40/F41.BMC infectious diseases · 2026Pooled it
- Diagnostic Accuracy of Multiplex NAAT/PCR and Culture AgainstPathogens (Basel, Switzerland) · 2025Pooled it
- Diagnostic accuracy of multiplex nucleic acid amplification tests forPathogens and global health · 2023Pooled it
- Efficacy of stool multiplex polymerase chain reaction assay in adult patients with acute infectious diarrhea.World journal of clinical cases · 2020Article
- Outcomes and clinical relevance of stool multiplex bacterial polymerase chain reaction in patients with acute diarrhea: single center experience.The Korean journal of internal medicine · 2020Article
- An Overview of the Molecular Methods in the Diagnosis of Gastrointestinal Infectious Diseases.International journal of microbiology · 2020Review
- Detection, Characterization, and Typing of Shiga Toxin-Producing Escherichia coli.Frontiers in microbiology · 2016Review
- Clinical Significance of Fecal Lactoferrin and Multiplex Polymerase Chain Reaction in Patients with Acute Diarrhea.Gut and liver · 2015Article
- Multiplex polymerase chain reaction tests for detection of pathogens associated with gastroenteritis.Clinics in laboratory medicine · 2015Review
- DNA microarray for detection of gastrointestinal viruses.Journal of clinical microbiology · 2015Article
- A parallel diagnostic accuracy study of three molecular panels for the detection of bacterial gastroenteritis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014Article
- A current overview of commercially available nucleic acid diagnostics approaches to detect and identify human gastroenteritis pathogens.Biomolecular detection and quantification · 2014Review
- Enteropathogen co-infection in UK cats with diarrhoea.BMC veterinary research · 2014Article
- The increasing application of multiplex nucleic acid detection tests to the diagnosis of syndromic infections.Epidemiology and infection · 2014Review
- A two-tube multiplex reverse transcription PCR assay for simultaneous detection of viral and bacterial pathogens of infectious diarrhea.BioMed research international · 2014Article
- Clinical evaluation of a real-time PCR assay for identification of Salmonella, Shigella, Campylobacter (Campylobacter jejuni and C. coli), and shiga toxin-producing Escherichia coli isolates in stool specimens.Journal of clinical microbiology · 2013Article
- Molecular-based diagnostics, including future trends.Medicine (Abingdon, England : UK ed.) · 2013Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A panel of 223 faecal samples was analysed to determine the clinical utility of the Seeplex® Diarrhea ACE Detection multiplex PCR system (Seeplex system; Seegene, Korea), a qualitative multiplexing PCR technology that enables simultaneous multi-pathogen detection of four viruses and/or ten bacteria associated with acute gastroenteritis. Conventional diagnostic methods and a norovirus-specific multiplex real-time RT–PCR detected 98 pathogens in 96 samples. The Seeplex system detected 81 pathogens in 75 samples. All samples positive for adenovirus, norovirus, Campylobacter spp., Escherichia coli O157, Shigella spp. or Vibrio spp. were detected by the Seeplex system. Rotavirus, Clostridium difficile toxin B, and Salmonella spp. were not detected in 12.5%, 50% and 15.8% of samples, respectively. Additional multiple infections were detected in 19 samples by the Seeplex system. The Seeplex system provides significant additional diagnostic capability for the syndromic diagnosis of acute gastroenteritis with increased sensitivity for the majority of pathogens.
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