ArticleVeterinary research2012
Equine sarcoids: Bovine Papillomavirus type 1 transformed fibroblasts are sensitive to cisplatin and UVB induced apoptosis and show aberrant expression of p53.
Article in Veterinary research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Equine Sarcoid: From BPV-Driven Oncogenesis to Host-Sustained Tumor Persistence.Pathogens (Basel, Switzerland) · 2026Review
- Development of immunodiagnostic tools for in situ investigation of Ovis aries papillomavirus 3 (OaPV3).Veterinary research communications · 2023Article
- Expression of Cell-Cycle Regulatory Proteins pRb, Cyclin D1, and p53 Is Not Associated with Recurrence Rates of Equine Sarcoids.Veterinary sciences · 2022Article
- Molecular detection of Papillomavirus and immunohistochemical investigation of p53 gene expressions in bovine papillomas and fibropapillomas.Archives of microbiology · 2022Article
- Clinico-Histopathological and Immunohistochemical Study of Ruminant's Cutaneous Papillomavirus in Iraq.Veterinary medicine international · 2020Article
- Oral sarcoid in a cat.The Canadian veterinary journal = La revue veterinaire canadienne · 2019Article
- Comparative transcriptomic analysis of bovine papillomatosis.BMC genomics · 2018Article
- Malignant transformation of canine oral papillomavirus (CPV1)-associated papillomas in dogs: An emerging concern?Papillomavirus research (Amsterdam, Netherlands) · 2018Article
- Ocular squamous cell carcinoma in Holstein cows from the South of Brazil.Veterinary world · 2017Article
- Expression of bcl-2 and p53 in bovine cutaneous fibropapillomas.Infectious agents and cancer · 2015Article
- BAG3 protects bovine papillomavirus type 1-transformed equine fibroblasts against pro-death signals.Veterinary research · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bovine papillomavirus type 1 infects not only cattle but also equids and is a causative factor in the pathogenesis of commonly occurring equine sarcoid tumours. Whilst treatment of sarcoids is notoriously difficult, cisplatin has been shown to be one of the most effective treatment strategies for sarcoids. In this study we show that in equine fibroblasts, BPV-1 sensitises cells to cisplatin-induced and UVB-induced apoptosis, a known cofactor for papillomavirus associated disease, however BPV-1 transformed fibroblasts show increased clonogenic survival, which may potentially limit the therapeutic effects of repeated cisplatin treatment. Furthermore we show that BPV-1 increases p53 expression in sarcoid cell lines and p53 expression can be either nuclear or cytoplasmic. The mechanism and clinical significance of increase/abnormal p53 expression remains to be established.
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Registered trials
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