ArticleGenes, brain, and behavior2013
Sexual differentiation in the developing mouse brain: contributions of sex chromosome genes.
Article in Genes, brain, and behavior, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 59 citations in OpenAlex.
- Sex does not influence neuronal autophagosome biogenesis throughout aging in mice.Molecular biology of the cell · 2025Article
- Roles of chromosomal and gonadal sex in the fetal and placental responses to maternal food restriction in mice.Molecular human reproduction · 2025Article
- A second X chromosome improves cognition in aging male and female mice.bioRxiv : the preprint server for biology · 2024Article
- A Transcriptomic Dataset of Embryonic Murine Telencephalon.Scientific data · 2024Article
- Adolescent social housing protects against adult emotional and cognitive deficits and alters the PFC and NAc transcriptome in male and female C57BL/6J mice.Frontiers in neuroscience · 2023Article
- The Placenta's Role in Sexually Dimorphic Fetal Growth Strategies.Reproductive sciences (Thousand Oaks, Calif.) · 2022Review
- X-linked histone H3K27 demethylase Kdm6a regulates sexually dimorphic differentiation of hypothalamic neurons.Cellular and molecular life sciences : CMLS · 2021Article
- Profiling of Sexually Dimorphic Genes in Neural Cells to IdentifyFrontiers in cell and developmental biology · 2021Article
- Autism Spectrum Disorder Genetics and the Search for Pathological Mechanisms.The American journal of psychiatry · 2021Review
- Four Core Genotypes and XY* mouse models: Update on impact on SABV research.Neuroscience and biobehavioral reviews · 2020Review
- Bisphenol a Exposure in Utero Disrupts Hypothalamic Gene Expression Particularly Genes Suspected in Autism Spectrum Disorders and Neuron and Hormone Signaling.International journal of molecular sciences · 2020Article
- Putative contributions of the sex chromosome proteins SOX3 and SRY to neurodevelopmental disorders.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2019Article
- The mouse as a model of fundamental concepts related to Turner syndrome.American journal of medical genetics. Part C, Seminars in medical genetics · 2019Review
- Gene regulatory mechanisms underlying sex differences in brain development and psychiatric disease.Annals of the New York Academy of Sciences · 2018Review
- Sex-Dependent Effects of Developmental Lead Exposure on the Brain.Frontiers in genetics · 2018Review
- Sexually Dimorphic Epigenetic Regulation of Brain-Derived Neurotrophic Factor in Fetal Brain in the Valproic Acid Model of Autism Spectrum Disorder.Developmental neuroscience · 2017Article
- Intermittent Ethanol during Adolescence Leads to Lasting Behavioral Changes in Adulthood and Alters Gene Expression and Histone Methylation in the PFC.Frontiers in molecular neuroscience · 2017Article
- The importance of having two X chromosomes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- A primer on the use of mouse models for identifying direct sex chromosome effects that cause sex differences in non-gonadal tissues.Biology of sex differences · 2016Review
- An integrative view on sex differences in brain tumors.Cellular and molecular life sciences : CMLS · 2015Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
Neural sexual differentiation begins during embryogenesis and continues after birth for a variable amount of time depending on the species and brain region. Because gonadal hormones were the first factors identified in neural sexual differentiation, their role in this process has eclipsed investigation of other factors. Here, we use a mouse with a spontaneous translocation that produces four different unique sets of sex chromosomes. Each genotype has one normal X-chromosome and a unique second sex chromosome creating the following genotypes: XY(*x) , XX, XY(*) , XX(Y) (*) . This Y(*) mouse line is used by several laboratories to study two human aneuploid conditions: Turner and Klinefelter syndromes. As sex chromosome number affects behavior and brain morphology, we surveyed brain gene expression at embryonic days 11.5 and 18.5 to isolate X-chromosome dose effects in the developing brain as possible mechanistic changes underlying the phenotypes. We compared gene expression differences between gonadal males and females as well as individuals with one vs. two X-chromosomes. We present data showing, in addition to genes reported to escape X-inactivation, a number of autosomal genes are differentially expressed between the sexes and in mice with different numbers of X-chromosomes. Based on our results, we can now identify the genes present in the region around the chromosomal break point that produces the Y(*) model. Our results also indicate an interaction between gonadal development and sex chromosome number that could further elucidate the role of sex chromosome genes and hormones in the sexual differentiation of behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.