ArticleAnnals of medical and health sciences research2011
Oxidative stress and glycaemic control in type 2 diabetic patients in enugu, South-East Nigeria.
Article in Annals of medical and health sciences research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed, 10 citations in OpenAlex.
- Relationship Between Oxidative Stress and Severity of Diabetic Foot Ulcers Among Patients With Type-2 Diabetes Mellitus in Japan: A Cross-Sectional Study.Health science reports · 2025Article
- Poor Glycaemic Control Is Associated with Increased Lipid Peroxidation and Glutathione Peroxidase Activity in Type 2 Diabetes Patients.Oxidative medicine and cellular longevity · 2019Article
- Urinary Malondialdehyde as a Biomarker of Type 2 Diabetes Mellitus Treatment in the Primary Care Unit of a Tertiary Care Hospital.Journal of primary care & community healthArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is growing evidence that excess generation of highly reactive free radicals, largely due to hyperglycaemia causes oxidative stress, which further exacerbates the development and progression of type 2 diabetes and its complications.
objectivesIn this study, the level of oxidative stress was compared with glycaemic control in type 2 diabetic patients.
methodFifty confirmed type 2 diabetic patients, aged between 25 and 70 years were used for the study. 20 patients with good glycaemic control served as positive control while 20 apparently healthy non-diabetic age-matched individuals served as negative control. The FBS, MDA and HbA(1) c were determined in fasting blood samples using standard methods.
resultsPatients with poor glycaemic control had significantly raised MDA and HbA(1)c (P =0.0001) when compared with non diabetics However, those with good glycaemic control only had a significant increase in the MDA when compared to non diabetic. (P =0.0001).).The MDA level when compared to fasting blood sugar (FBS) and glycated haemoglobin (HbA(1)c) showed a positive correlation.( r= 0.77; P = 0.0001 and r=0.69; P = 0.0001 respectively)
conclusionThis study showed that both glycaemic control and lipid peroxidation are factors to be monitored or evaluated in the management of type2 diabetics to avoid the development of diabetic complications.
Identifiers
23209965PMC3507100W2110541611What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.