ArticleJournal of parasitology research2012
Changes in T-Cell and Monocyte Phenotypes In Vitro by Schistosoma mansoni Antigens in Cutaneous Leishmaniasis Patients.
Article in Journal of parasitology research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 9 citations in OpenAlex.
- The Sm29 antigen differentially shapes transcriptomic and regulatory landscapes across reactional forms of leprosy.Frontiers in immunology · 2026Article
- Co-endemicity of schistosomiasis and tegumentary leishmaniasis: Spatial co-clustering in endemic areas.Tropical medicine & international health : TM & IH · 2025Article
- Review
- Leishmania donovani molecules recognized by sera of filaria infected host facilitate filarial infection.Parasitology research · 2018Article
- Schistosoma mansoni SmKI-1 serine protease inhibitor binds to elastase and impairs neutrophil function and inflammation.PLoS pathogens · 2018Article
- Susceptibility of dendritic cells from individuals with schistosomiasis to infection by Leishmania braziliensis.Molecular immunology · 2018Article
- Article
- A double edged sword: Schistosoma mansoni Sm29 regulates both Th1 and Th2 responses in inflammatory mucosal diseases.Mucosal immunology · 2016Review
- Monocyte subsets in schistosomiasis patients with periportal fibrosis.Mediators of inflammation · 2014Article
- Dendritic cell profile induced by Schistosoma mansoni antigen in cutaneous leishmaniasis patients.BioMed research international · 2014Article
Corrections and comments
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Authors and funding
8 authors at 7 institutions in 2 countries.
Funding
Abstract
High levels of proinflammatory cytokines such as IFN-γ and TNF are associated with tissue lesions in cutaneous leishmaniasis (CL). We previously demonstrated that Schistosoma mansoni antigens downmodulate the in vitro cytokine response in CL. In the current study we evaluated whether S. mansoni antigens alter monocyte and T-lymphocyte phenotypes in leishmaniasis. Peripheral blood mononuclear cells of CL patients were cultured with L. braziliensis antigen in the presence or absence of the S. mansoni antigens rSm29, rSmTSP-2- and PIII. Cells were stained with fluorochrome conjugated antibodies and analyzed by flow cytometry. The addition of rSm29 to the cultures decreased the expression of HLA-DR in nonclassical (CD14(+)CD16(++)) monocytes, while the addition of PIII diminished the expression of this molecule in classical (CD14(++)CD16(-)) and intermediate (CD14(++)CD16(+)) monocytes. The addition of PIII and rSmTSP-2 resulted in downmodulation of CD80 expression in nonclassical and CD86 expression in intermediate monocytes, respectively. These two antigens increased the expression of CTLA-4 in CD4(+) T cells and they also expanded the frequency of CD4(+)CD25(high)Foxp3(+) T cells. Taken together, we show that S. mansoni antigens, mainly rSmTSP-2 and PIII, are able to decrease the activation status of monocytes and also to upregulate the expression of modulatory molecules in T lymphocytes.
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Registered trials
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