ArticleScientific reports2012
Accelerated crossing of fitness valleys through division of labor and cheating in asexual populations.
Article in Scientific reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Time scales and wave formation in non-linear spatial public goods games.PLoS computational biology · 2019Article
- Passenger mutations can accelerate tumour suppressor gene inactivation in cancer evolution.Journal of the Royal Society, Interface · 2018Article
- Contribution of HIV-1 genomes that do not integrate to the basic reproductive ratio of the virus.Journal of theoretical biology · 2015Article
- Collapse of cooperation in evolving games.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Spatial interactions and cooperation can change the speed of evolution of complex phenotypes.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Complex traits can require the accumulation of multiple mutations that are individually deleterious. Their evolution requires a fitness valley to be crossed, which can take relatively long time spans. A new evolutionary mechanism is described that accelerates the emergence of complex phenotypes, based on a "division of labor" game and the occurrence of cheaters. If each intermediate mutation leads to a product that can be shared with others, the complex type can arise relatively quickly as an emergent property among cooperating individuals, without any given individual having to accumulate all mutations. Moreover, the emergence of cheaters that destroy cooperative interactions can lead to the emergence of individuals that have accumulated all necessary mutations on a time scale that is significantly faster than observed in the absence of cooperation and cheating. Application of this mechanism to somatic and microbial evolution is discussed, including evolutionary processes in tumors, biofilms, and viral infections.
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