ArticlePLoS neglected tropical diseases2012
Endemic foci of the tick-borne relapsing fever spirochete Borrelia crocidurae in Mali, West Africa, and the potential for human infection.
Article in PLoS neglected tropical diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 69 citations in OpenAlex.
- Quantitative polymerase chain reaction from malaria rapid diagnostic tests to detect Borrelia crocidurae in Mali.PLoS neglected tropical diseases · 2026Article
- Serological evidence of Borrelia turicatae in Raccoons (Procyon lotor) from an endemic focus of tick-borne relapsing fever in Mexico.PLoS neglected tropical diseases · 2026Article
- Mitochondrial 16S rDNA sequences help identify North American ticks in the genus Argas (Acari: Argasidae).Journal of medical entomology · 2025Article
- Development and validation of systems for genetic manipulation of the Old World tick-borne relapsing fever spirochete, Borrelia duttonii.PLoS neglected tropical diseases · 2024Article
- Article
- Experimental transmission of a novel relapsing fever group Borrelia harbored by Ornithodoros octodontus (Ixodida: Argasidae) in Chile.Experimental & applied acarology · 2024Article
- Investigating the etiologies of non-malarial febrile illness in Senegal using metagenomic sequencing.Nature communications · 2024Article
- Tick-Borne Diseases of Humans and Animals in West Africa.Pathogens (Basel, Switzerland) · 2023Review
- Quantitative Polymerase Chain Reaction from Malaria Rapid Diagnostic Tests to Detect Borrelia crocidurae, the Agent of Tick-Borne Relapsing Fever, in Febrile Patients in Senegal.The American journal of tropical medicine and hygiene · 2023Article
- Molecular Surveillance for Vector-Borne Bacteria in Rodents and Tree Shrews of Peninsular Malaysia Oil Palm Plantations.Tropical medicine and infectious disease · 2023Article
- Detection of Old and New World Relapsing Fever Borreliae inMicroorganisms · 2023Article
- Article
- Diversity and distribution of the tick-borne relapsing fever spirochete Borrelia turicatae.PLoS neglected tropical diseases · 2021Article
- Transmission of the Human Relapsing Fever Spirochete Borrelia persica by the Argasid Tick Ornithodoros tholozani Involves Blood Meals from Wildlife Animal Reservoirs and Mainly Transstadial Transfer.Applied and environmental microbiology · 2021Article
- Article
- Tick-borne relapsing fever Borreliosis, a major public health problem overlooked in Senegal.PLoS neglected tropical diseases · 2021Article
- Article
- Molecular Detection of Microorganisms Associated with Small Mammals and Their Ectoparasites in Mali.The American journal of tropical medicine and hygiene · 2020Article
- Surveillance forVeterinary sciences · 2020Article
- Host Competency of the Multimammate RatThe American journal of tropical medicine and hygiene · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundTick-borne relapsing fever spirochetes are maintained in endemic foci that involve a diversity of small mammals and argasid ticks in the genus Ornithodoros. Most epidemiological studies of tick-borne relapsing fever in West Africa caused by Borrelia crocidurae have been conducted in Senegal. The risk for humans to acquire relapsing fever in Mali is uncertain, as only a few human cases have been identified. Given the high incidence of malaria in Mali, and the potential to confuse the clinical diagnosis of these two diseases, we initiated studies to determine if there were endemic foci of relapsing fever spirochetes that could pose a risk for human infection. METHODOLOGY/PRINCIPAL
findingsWe investigated 20 villages across southern Mali for the presence of relapsing fever spirochetes. Small mammals were captured, thin blood smears were examined microscopically for spirochetes, and serum samples were tested for antibodies to relapsing fever spirochetes. Ornithodoros sonrai ticks were collected and examined for spirochetal infection. In total, 11.0% of the 663 rodents and 14.3% of the 63 shrews tested were seropositive and 2.2% of the animals had active spirochete infections when captured. In the Bandiagara region, the prevalence of infection was higher with 35% of the animals seropositive and 10% infected. Here also Ornithodoros sonrai were abundant and 17.3% of 278 individual ticks tested were infected with Borrelia crocidurae. Fifteen isolates of B. crocidurae were established and characterized by multi-locus sequence typing. CONCLUSIONS/SIGNIFICANCE: The potential for human tick-borne relapsing fever exists in many areas of southern Mali.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.