SynthesisPLoS neglected tropical diseases2012
Human african trypanosomiasis diagnosis in first-line health services of endemic countries, a systematic review.
Synthesis in PLoS neglected tropical diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed.
- Sensitivity and specificity of HAT Bioline AbbottParasites & vectors · 2026Article
- Control of Human African Trypanosomiasis in the Nola-Bilolo Focus, Central African Republic, 2020-2024: Outcome of Capacity Building, Improved Diagnosis and Treatment.Journal of parasitology research · 2026Article
- Prospective evaluation of 2nd generation rapid diagnostic tests for the serological diagnosis of gambiense human African trypanosomiasis in the Democratic Republic of the Congo.BMC infectious diseases · 2025Observational
- Retrospective clinical performance evaluation of the Abbott Bioline HAT 2.0, a rapid diagnostic test for human African trypanosomiasis based on recombinant antigens.Tropical medicine & international health : TM & IH · 2025Article
- Specificity of serological screening tests and reference laboratory tests to diagnose gambiense human African trypanosomiasis: a prospective clinical performance study.Infectious diseases of poverty · 2024Article
- Health economic evaluation of strategies to eliminate gambiense human African trypanosomiasis in the Mandoul disease focus of Chad.PLoS neglected tropical diseases · 2023Article
- A review on the diagnosis of animal trypanosomoses.Parasites & vectors · 2022Review
- Laboratory Diagnosis of Tropical Infections.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2021Article
- Cost of a new method of active screening for human African trypanosomiasis in the Democratic Republic of the Congo.PLoS neglected tropical diseases · 2020Article
- Development of a bio-inkjet printed LAMP test kit for detecting human African trypanosomiasis.PLoS neglected tropical diseases · 2020Article
- Development and implementation of a strategy for intensified screening for gambiense human African trypanosomiasis in Kongo Central province, DRC.PLoS neglected tropical diseases · 2020Article
- The complex health seeking pathway of a human African trypanosomiasis patient in Côte d'Ivoire underlines the need of setting up passive surveillance systems.PLoS neglected tropical diseases · 2020Article
- In Vitro Studies on Antioxidant and Anti-Parasitic Activities of Compounds Isolated fromMolecules (Basel, Switzerland) · 2020Article
- Detection of Rare Objects by Flow Cytometry: Imaging, Cell Sorting, and Deep Learning Approaches.International journal of molecular sciences · 2020Review
- Integration of Human African Trypanosomiasis Control Activities into Primary Healthcare Services: A Scoping Review.The American journal of tropical medicine and hygiene · 2019Article
- Passive Screening and Diagnosis of Sleeping Sickness with New Tools in Primary Health Services: An Operational Research.Infectious diseases and therapy · 2019Article
- A scoping review on the field validation and implementation of rapid diagnostic tests for vector-borne and other infectious diseases of poverty in urban areas.Infectious diseases of poverty · 2018Article
- Prospective evaluation of a rapid diagnostic test for Trypanosoma brucei gambiense infection developed using recombinant antigens.PLoS neglected tropical diseases · 2018Article
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Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While the incidence of Human African Trypanosomiasis (HAT) is decreasing, the control approach is shifting from active population screening by mobile teams to passive case detection in primary care centers. We conducted a systematic review of the literature between 1970 and 2011 to assess which diagnostic tools are most suitable for use in first-line health facilities in endemic countries. Our search retrieved 16 different screening and confirmation tests for HAT. The thermostable format of the Card Agglutination Test for Trypanosomiasis (CATT test) was the most appropriate screening test. Lateral flow antibody detection tests could become alternative screening tests in the near future. Confirmation of HAT diagnosis still depends on visualizing the parasite in direct microscopy. All other currently available confirmation tests are either technically too demanding and/or lack sensitivity and thus rather inappropriate for use at health center level. Novel applications of molecular tests may have potential for use at district hospital level.
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