ArticlePloS one2012
Molecular evolution of hemagglutinin (H) gene in measles virus genotypes D3, D5, D9, and H1.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Characteristics and Genomic Diversity of Measles Virus From Measles Cases With Known Vaccination Status in Shanghai, China.Frontiers in medicine · 2022Article
- Article
- Antigenic Drift Defines a New D4 Subgenotype of Measles Virus.Journal of virology · 2017Article
- Molecular evolution of haemagglutinin (H) gene in measles virus.Scientific reports · 2015Article
- Molecular evolution of the VP1, VP2, and VP3 genes in human rhinovirus species C.Scientific reports · 2015Article
- Measles Virus Epitope Presentation by HLA: Novel Insights into Epitope Selection, Dominance, and Microvariation.Frontiers in immunology · 2015Article
- Evolutionary genetics of genotype H1 measles viruses in China from 1993 to 2012.The Journal of general virology · 2014Article
- Vaccine chronicle in Japan.Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy · 2013Review
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Authors and funding
16 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We studied the molecular evolution of H gene in four prevalent Asian genotypes (D3, D5, D9, and H1) of measles virus (MeV). We estimated the evolutionary time scale of the gene by the bayesian Markov Chain Monte Carlo (MCMC) method. In addition, we predicted the changes in structure of H protein due to selective pressures. The phylogenetic tree showed that the first division of these genotypes occurred around 1931, and further division of each type in the 1960-1970s resulted in four genotypes. The rate of molecular evolution was relatively slow (5.57×10(-4) substitutions per site per year). Only two positively selected sites (F476L and Q575K) were identified in H protein, although these substitutions might not have imparted significant changes to the structure of the protein or the epitopes for phylactic antibodies. The results suggested that the prevalent Asian MeV genotypes were generated over approximately 30-40 years and H protein was well conserved.
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