ArticlePloS one2012
A catalytic role of XoxF1 as La3+-dependent methanol dehydrogenase in Methylobacterium extorquens strain AM1.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.
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96 citing papers in PubMed, 231 citations in OpenAlex.
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- A lanmodulin homologous protein, from Mesorhizobium qingshengii J19, involved in yttrium immobilization.Scientific reports · 2026Article
- Beneath the surface: expanding the known repertoire of methylotrophic metabolism.Applied and environmental microbiology · 2026Article
- Comparative Binding Studies of the Chelators Methylolanthanin and Rhodopetrobactin B to Lanthanides and Ferric Iron.Chembiochem : a European journal of chemical biology · 2026Article
- Integrated genomic and transcriptomic Insights into methanol tolerance mechanisms in Methylobacterium extorquens AM1, identifying key targets for strain engineering.Journal of biological engineering · 2025Article
- Pink powerhouses: insights into the multifaceted role of Methylobacterium in climate-resilient farming.Folia microbiologica · 2025Review
- Expanding on the ability of trivalent actinides to support microbial alcohol metabolism in evolved methylotrophic bacterium.Communications chemistry · 2025Article
- XoxF and the Calvin-Benson cycle mediate lanthanide-dependent growth on methanol inApplied and environmental microbiology · 2025Article
- Diversity and distribution of the lanthanome in aerobic methane-oxidising bacteria.Environmental microbiome · 2025Article
- Feasibility of anaerobic co-digestion for biogas production from recycled paper industry sludge: optimization of mixing ratios and application in two-stage CSTR system design.Water science and technology : a journal of the International Association on Water Pollution Research · 2025Article
- Lanthanide-dependent isolation of phyllosphere methylotrophs selects for a phylogenetically conserved but metabolically diverse community.bioRxiv : the preprint server for biology · 2025Article
- Recent advances in metallophore research uncover functions in quorum sensing, antimicrobial activity, and lanthanide acquisition.Current opinion in chemical biology · 2025Review
- Methylobacterium extorquens PA1 utilizes multiple strategies to maintain formaldehyde homeostasis during methylotrophic growth.PLoS genetics · 2025Article
- Extensive and diverse lanthanide-dependent metabolism in the ocean.The ISME journal · 2025Article
- Emerging role of rare earth elements in biomolecular functions.The ISME journal · 2025Review
- Microbial green synthesis of luminescent terbium sulfide nanoparticles using E. Coli: a rare earth element detoxification mechanism.Microbial cell factories · 2024Article
- Structure-driven development of a biomimetic rare earth artificial metalloprotein.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Identification and characterization of a small-molecule metallophore involved in lanthanide metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Biotechnological potential of psychrotolerant methylobacteria isolated from biotopes of Antarctic oases.Archives of microbiology · 2024Article
36 more citing papers are in PubMed but not listed here.
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8 authors at 4 institutions in 1 country.
Funding
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Abstract
In the methylotrophic bacterium Methylobacterium extorquens strain AM1, MxaF, a Ca(2+)-dependent methanol dehydrogenase (MDH), is the main enzyme catalyzing methanol oxidation during growth on methanol. The genome of strain AM1 contains another MDH gene homologue, xoxF1, whose function in methanol metabolism has remained unclear. In this work, we show that XoxF1 also functions as an MDH and is La(3+)-dependent. Despite the absence of Ca(2+) in the medium strain AM1 was able to grow on methanol in the presence of La(3+). Addition of La(3+) increased MDH activity but the addition had no effect on mxaF or xoxF1 expression level. We purified MDH from strain AM1 grown on methanol in the presence of La(3+), and its N-terminal amino acid sequence corresponded to that of XoxF1. The enzyme contained La(3+) as a cofactor. The ΔmxaF mutant strain could not grow on methanol in the presence of Ca(2+), but was able to grow after supplementation with La(3+). Taken together, these results show that XoxF1 participates in methanol metabolism as a La(3+)-dependent MDH in strain AM1.
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