ArticlePloS one2012
The dyslexia candidate locus on 2p12 is associated with general cognitive ability and white matter structure.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- A systematic review and meta-analysis of imaging genetics studies of specific reading disorder.Cognitive neuropsychology · 2021Pooled it
- Language impairment and dyslexia genes influence language skills in children with autism spectrum disorders.Autism research : official journal of the International Society for Autism Research · 2015Pooled it
- The Polygenic Nature and Complex Genetic Architecture of Specific Learning Disorder.Brain sciences · 2021Review
- Identifying interactive biological pathways associated with reading disability.Brain and behavior · 2020Article
- Putative protective neural mechanisms in prereaders with a family history of dyslexia who subsequently develop typical reading skills.Human brain mapping · 2020Article
- Neuroimaging genetics studies of specific reading disability and developmental language disorder: A review.Language and linguistics compass · 2019Article
- Genetics of language and its implications on language interventions.Journal of genetics · 2018Review
- No evidence for cerebellar abnormality in adults with developmental dyslexia.Experimental brain research · 2018Article
- Article
- Identification of NCAN as a candidate gene for developmental dyslexia.Scientific reports · 2017Article
- Neurobiological bases of reading disorder Part I: Etiological investigations.Language and linguistics compass · 2017Article
- Development of Tract-Specific White Matter Pathways During Early Reading Development in At-Risk Children and Typical Controls.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Neurogenetics of developmental dyslexia: from genes to behavior through brain neuroimaging and cognitive and sensorial mechanisms.Translational psychiatry · 2017Review
- [Research advances in susceptible genes for developmental dyslexia in children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2016Review
- A sequence variant associating with educational attainment also affects childhood cognition.Scientific reports · 2016Article
- Lessons to be learned: how a comprehensive neurobiological framework of atypical reading development can inform educational practice.Current opinion in behavioral sciences · 2016Article
- Disrupted white matter connectivity underlying developmental dyslexia: A machine learning approach.Human brain mapping · 2016Article
- Dyslexia and language impairment associated genetic markers influence cortical thickness and white matter in typically developing children.Brain imaging and behavior · 2016Article
- Insights into the genetic foundations of human communication.Neuropsychology review · 2015Review
- DCDC2 polymorphism is associated with left temporoparietal gray and white matter structures during development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 8 institutions in 4 countries.
Funding
Abstract
Independent studies have shown that candidate genes for dyslexia and specific language impairment (SLI) impact upon reading/language-specific traits in the general population. To further explore the effect of disorder-associated genes on cognitive functions, we investigated whether they play a role in broader cognitive traits. We tested a panel of dyslexia and SLI genetic risk factors for association with two measures of general cognitive abilities, or IQ, (verbal and non-verbal) in the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort (N>5,000). Only the MRPL19/C2ORF3 locus showed statistically significant association (minimum P = 0.00009) which was further supported by independent replications following analysis in four other cohorts. In addition, a fifth independent sample showed association between the MRPL19/C2ORF3 locus and white matter structure in the posterior part of the corpus callosum and cingulum, connecting large parts of the cortex in the parietal, occipital and temporal lobes. These findings suggest that this locus, originally identified as being associated with dyslexia, is likely to harbour genetic variants associated with general cognitive abilities by influencing white matter structure in localised neuronal regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.