ArticlePloS one2012
Parental diabetes: the Akita mouse as a model of the effects of maternal and paternal hyperglycemia in wildtype offspring.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Gestational diabetes in mice induces hematopoietic memory that affects the long-term health of the offspring.The Journal of clinical investigation · 2024Article
- Metabolites and Genes behind Cardiac Metabolic Remodeling in Mice with Type 1 Diabetes Mellitus.International journal of molecular sciences · 2022Article
- Exposure to maternal high-fat diet induces extensive changes in the brain of adult offspring.Translational psychiatry · 2021Article
- Effect of Postnatal Nutritional Environment Due to Maternal Diabetes on Beta Cell Mass Programming and Glucose Intolerance Risk in Male and Female Offspring.Biomolecules · 2021Article
- Prenatal Hyperglycemia Exposure and Cellular Stress, a Sugar-Coated View of Early Programming of Metabolic Diseases.Biomolecules · 2020Review
- Parental metabolic syndrome epigenetically reprograms offspring hepatic lipid metabolism in mice.The Journal of clinical investigation · 2020Article
- Paternal metabolic and cardiovascular programming of their offspring: A systematic scoping review.PloS one · 2020Article
- Effects of fetal exposure to high-fat diet or maternal hyperglycemia on L-arginine and nitric oxide metabolism in lung.Nutrition & diabetes · 2017Article
- A new perspective on mechanisms governing skeletal complications in type 1 diabetes.Annals of the New York Academy of Sciences · 2016Review
- Review
- Sex-Differences in the Metabolic Health of Offspring of Parents with Diabetes: A Record-Linkage Study.PloS one · 2015Article
- Male obesity and subfertility, is it really about increased adiposity?Asian journal of andrologyReview
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
Abstract
aim/hypothesisMaternal diabetes and high-fat feeding during pregnancy have been linked to later life outcomes in offspring. To investigate the effects of both maternal and paternal hyperglycemia on offspring phenotypes, we utilized an autosomal dominant mouse model of diabetes (hypoinsulinemic hyperglycemia in Akita mice). We determined metabolic and skeletal phenotypes in wildtype offspring of Akita mothers and fathers.
resultsBoth maternal and paternal diabetes resulted in phenotypic changes in wildtype offspring. Phenotypic changes were more pronounced in male offspring than in female offspring. Maternal hyperglycemia resulted in metabolic and skeletal phenotypes in male wildtype offspring. Decreased bodyweight and impaired glucose tolerance were observed as were reduced whole body bone mineral density and reduced trabecular bone mass. Phenotypic changes in offspring of diabetic fathers differed in effect size from changes in offspring of diabetic mothers. Male wildtype offspring developed a milder metabolic phenotype, but a more severe skeletal phenotype. Female wildtype offspring of diabetic fathers were least affected.
conclusionsBoth maternal and paternal diabetes led to the development of metabolic and skeletal changes in wildtype offspring, with a greater effect of maternal diabetes on metabolic parameters and of paternal diabetes on skeletal development. The observed changes are unlikely to derive from Mendelian inheritance, since the investigated offspring did not inherit the Akita mutation. While fetal programming may explain the phenotypic changes in offspring exposed to maternal diabetes in-utero, the mechanism underlying the effect of paternal diabetes on wildtype offspring is unclear.
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