ArticlePloS one2012
Investigating the genetic basis of theory of mind (ToM): the role of catechol-O-methyltransferase (COMT) gene polymorphisms.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Serotonin and Dopamine Gene Variation and Theory of Mind Decoding Accuracy in Major Depression: A Preliminary Investigation.PloS one · 2016Trial
- Gender differences in empathy, compassion, and prosocial donations, but not theory of mind in a naturalistic social task.Scientific reports · 2023Article
- Decoding emotion of the other differs among schizophrenia patients and schizoaffective patients: A pilot study.Schizophrenia research. Cognition · 2016Article
- Modulative effects of COMT haplotype on age-related associations with brain morphology.Human brain mapping · 2016Article
- Theory of mind network activity is altered in subjects with familial liability for schizophrenia.Social cognitive and affective neuroscience · 2016Article
- Empathy as a "risky strength": a multilevel examination of empathy and risk for internalizing disorders.Development and psychopathology · 2014Review
- Pain in Parkinson's disease associated with COMT gene polymorphisms.Behavioural neurology · 2014Article
- A Case of Transient Global Amnesia: A Review and How It May Shed Further Insight into the Neurobiology of Delusions.Innovations in clinical neuroscienceArticle
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability to deduce other persons' mental states and emotions which has been termed 'theory of mind (ToM)' is highly heritable. First molecular genetic studies focused on some dopamine-related genes, while the genetic basis underlying different components of ToM (affective ToM and cognitive ToM) remain unknown. The current study tested 7 candidate polymorphisms (rs4680, rs4633, rs2020917, rs2239393, rs737865, rs174699 and rs59938883) on the catechol-O-methyltransferase (COMT) gene. We investigated how these polymorphisms relate to different components of ToM. 101 adults participated in our study; all were genetically unrelated, non-clinical and healthy Chinese subjects. Different ToM tasks were applied to detect their theory of mind ability. The results showed that the COMT gene rs2020917 and rs737865 SNPs were associated with cognitive ToM performance, while the COMT gene rs5993883 SNP was related to affective ToM, in which a significant gender-genotype interaction was found (p = 0.039). Our results highlighted the contribution of DA-related COMT gene on ToM performance. Moreover, we found out that the different SNP at the same gene relates to the discriminative aspect of ToM. Our research provides some preliminary evidence to the genetic basis of theory of mind which still awaits further studies.
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