ArticlePloS one2012
Modelling HIV and MTB co-infection including combined treatment strategies.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Joint spatiotemporal modelling of tuberculosis and human immunodeficiency virus in Ethiopia using a Bayesian hierarchical approach.BMC public health · 2025Article
- Reduced HIV/AIDS diagnosis rates and increased AIDS mortality due to late diagnosis in Brazil during the COVID-19 pandemic.Scientific reports · 2023Article
- Article
- The COVID-19, tuberculosis and HIV/AIDS: Ménage à Trois.Frontiers in immunology · 2023Review
- Spatial Clustering of Tuberculosis-HIV Coinfection in Ethiopia at Districts Level.AIDS research and treatment · 2023Article
- Spatial Co-Clustering of Tuberculosis and HIV in Ethiopia.Diseases (Basel, Switzerland) · 2022Article
- Systems biology approaches to investigate the role of granulomas in TB-HIV coinfection.Frontiers in immunology · 2022Review
- TheFuture virology · 2020Review
- Article
- An update on granulomatous diseases of the oral tissues.Dental clinics of North America · 2013Review
- Latent Tuberculosis: Models, Computational Efforts and the Pathogen's Regulatory Mechanisms during Dormancy.Frontiers in bioengineering and biotechnology · 2013Review
- Mathematical modeling of the HIV/Kaposi's sarcoma coinfection dynamics in areas of high HIV prevalence.Computational and mathematical methods in medicine · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A new host-pathogen model is described that simulates HIV-MTB co-infection and treatment, with the objective of testing treatment strategies. The model includes CD4+ and CD8+ T cells, resting and activated macrophages, HIV and Mycobacterium tuberculosis (MTB). For TB presentation at various stages of HIV disease in a co-infected individual, combined treatment strategies were tested with different relative timings of treatment for each infection. The stages were early HIV disease, late HIV disease and AIDS. The main strategies were TB treatment followed by anti-retroviral therapy (ART) after delays of 15 days, 2 months and 6 months. ART followed by TB treatment was an additional strategy that was tested. Treatment was simulated with and without drug interaction. Simulation results were that TB treatment first followed by ART after a stage-dependent delay has the best outcome. During early HIV disease a 6 month delay is acceptable. During late HIV disease, a 2 month delay is best. During AIDS it is better to start ART after 15 days. However, drug interaction works against the benefits of early ART. These results agree with expert reviews and clinical trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.