ArticlePloS one2012
5-HTTLPR and early childhood adversities moderate cognitive and emotional processing in adolescence.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Executive function and attention in children and adolescents with depressive disorders: a systematic review.European child & adolescent psychiatry · 2015Pooled it
- Serotonin transporter linked polymorphic region (5-HTTLPR) genotype moderates the longitudinal impact of early caregiving on externalizing behavior.Development and psychopathology · 2015Trial
- Symbiotic interactions of dark septate endophytic fungi on shallot growth under drought stress.Archives of microbiology · 2026Article
- Dimensions of Early-Life Adversity and Attention Biases in Childhood and Adolescence: A Systematic Review.Clinical child and family psychology review · 2026Review
- Behavioral measures of impulsivity and compulsivity in adolescents with nonsuicidal self-injury.CNS spectrums · 2022Article
- Affective Processing Biases in Relation to Past, Current, and Future Depression in Children and Adolescents.Journal of affective disorders · 2020Article
- Gender Differences in Child Abuse, Emotional Processing Difficulties, Alexithymia, Psychological Symptoms and Behavioural Problems among Chinese Adolescents.The Psychiatric quarterly · 2020Article
- Article
- Early life stress predicts negative urgency through brooding, depending on 5-HTTLPR genotype: A pilot study with 6-month follow-up examining suicide ideation.Psychiatry research · 2017Article
- The interaction between 5-HTTLPR and stress exposure influences connectivity of the executive control and default mode brain networks.Brain imaging and behavior · 2017Observational
- Child Abuse and Psychiatric Co-morbidity Among Chinese Adolescents: Emotional Processing as Mediator and PTSD from Past Trauma as Moderator.Child psychiatry and human development · 2017Article
- Article
- The Relationship Between Gender, Posttraumatic Stress Disorder from Past Trauma, Alexithymia and Psychiatric Co-morbidity in Chinese Adolescents: A Moderated Mediational Analysis.The Psychiatric quarterly · 2016Article
- Aberrant brain responses to emotionally valent words is normalised after cognitive behavioural therapy in female depressed adolescents.Journal of affective disorders · 2016Article
- Perceived Parenting Mediates Serotonin Transporter Gene (5-HTTLPR) and Neural System Function during Facial Recognition: A Pilot Study.PloS one · 2015Article
- Elevated morning cortisol is a stratified population-level biomarker for major depression in boys only with high depressive symptoms.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Article
- Effects of repeated adolescent stress and serotonin transporter gene partial knockout in mice on behaviors and brain structures relevant to major depression.Frontiers in behavioral neuroscience · 2013Article
- Role of 5-HTTLPR polymorphism in the development of the inward/outward personality organization: a genetic association study.PloS one · 2013Article
- Prenatal serotonin reuptake inhibitor (SRI) antidepressant exposure and serotonin transporter promoter genotype (SLC6A4) influence executive functions at 6 years of age.Frontiers in cellular neuroscience · 2013Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundPolymorphisms in the promoter region of the serotonin transporter gene (5-HTTLPR) and exposure to early childhood adversities (CA) are independently associated with individual differences in cognitive and emotional processing. Whether these two factors interact to influence cognitive and emotional processing is not known. METHODOLOGY AND PRINCIPAL
findingsWe used a sample of 238 adolescents from a community study characterised by the presence of the short allele of 5-HTTLPR (LL, LS, SS) and the presence or absence of exposure to CA before 6 years of age. We measured cognitive and emotional processing using a set of neuropsychological tasks selected predominantly from the CANTAB® battery. We found that adolescents homozygous for the short allele (SS) of 5-HTTLPR and exposed to CA were worse at classifying negative and neutral stimuli and made more errors in response to ambiguous negative feedback. In addition, cognitive and emotional processing deficits were associated with diagnoses of anxiety and/or depressions. CONCLUSION AND SIGNIFICANCE: Cognitive and emotional processing deficits may act as a transdiagnostic intermediate marker for anxiety and depressive disorders in genetically susceptible individuals exposed to CA.
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