ArticlePLoS genetics2012
Deubiquitylation machinery is required for embryonic polarity in Caenorhabditis elegans.
Article in PLoS genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Proximity-dependent biotinylation reveals an interaction between ubiquitin-specific peptidase 46 and centrosome-related proteins.FEBS open bio · 2025Article
- USP7 regulates ALS-associated proteotoxicity and quality control through the NEDD4L-SMAD pathway.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Going with the flow: insights fromPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Patterning and polarization of cells by intracellular flows.Current opinion in cell biology · 2020Review
- Investigating Mechanisms that Control Ubiquitin-Mediated DAF-16/FOXO Protein Turnover.Methods in molecular biology (Clifton, N.J.) · 2019Article
- Sustained centrosome-cortical contact ensures robust polarization of the one-cell C. elegans embryo.Developmental biology · 2017Article
- A Network of Chromatin Factors Is Regulating the Transition to Postembryonic Development inG3 (Bethesda, Md.) · 2017Article
- A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.Molecular & cellular proteomics : MCP · 2015Article
- The Deubiquitylase MATH-33 Controls DAF-16 Stability and Function in Metabolism and Longevity.Cell metabolism · 2015Article
- The WD40-repeat proteins WDR-20 and WDR-48 bind and activate the deubiquitinating enzyme USP-46 to promote the abundance of the glutamate receptor GLR-1 in the ventral nerve cord of Caenorhabditis elegans.The Journal of biological chemistry · 2014Article
- Principles of PAR polarity in Caenorhabditis elegans embryos.Nature reviews. Molecular cell biology · 2013Review
- The PAR network: redundancy and robustness in a symmetry-breaking system.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- Ubiquitin-specific proteases 25 negatively regulates virus-induced type I interferon signaling.PloS one · 2013Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
The Caenorhabditis elegans one-cell embryo polarizes in response to a cue from the paternally donated centrosome and asymmetrically segregates cell fate determinants that direct the developmental program of the worm. We have found that genes encoding putative deubiquitylating enzymes (DUBs) are required for polarization of one-cell embryos. Maternal loss of the proteins MATH-33 and USP-47 leads to variable inability to correctly establish and maintain asymmetry as defined by posterior and anterior polarity proteins PAR-2 and PAR-3. The first observable defect is variable positioning of the centrosome with respect to the cell cortex and the male pronucleus. The severity of the polarity defects correlates with distance of the centrosome from the cortex. Furthermore, polarity defects can be bypassed by mutations that bring the centrosome in close proximity to the cortex. In addition we find that polarity and centrosome positioning defects can be suppressed by compromising protein turnover. We propose that the DUB activity of MATH-33 and USP-47 stabilizes one or more proteins required for association of the centrosome with the cortex. Because these DUBs are homologous to two members of a group of DUBs that act in fission yeast polarity, we tested additional members of that family and found that another C. elegans DUB gene, usp-46, also contributes to polarity. Our finding that deubiquitylating enzymes required for polarity in Schizosaccharomyces pombe are also required in C. elegans raises the possibility that these DUBs act through an evolutionarily conserved mechanism to control cell polarity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.