ArticlePLoS pathogens2012
A trade-off between the fitness cost of functional integrases and long-term stability of integrons.
Article in PLoS pathogens, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 52 citations in OpenAlex.
- Integrons: the hidden architects of bacterial adaptation, evolution, and the challenges of antimicrobial resistance.Antonie van Leeuwenhoek · 2025Review
- Biofilms preserve the transmissibility of a multi-drug resistance plasmid.NPJ biofilms and microbiomes · 2022Article
- Activation of class 1 integron integrase is promoted in the intestinal environment.PLoS genetics · 2022Article
- Antibiofilm Activity of β-Lactam/β-Lactamase Inhibitor Combination against Multidrug-ResistantPathogens (Basel, Switzerland) · 2022Article
- Unbridled Integrons: A Matter of Host Factors.Cells · 2022Review
- Bacterial evolution on demand.eLife · 2021Article
- Article
- Promoter activity of ORF-less gene cassettes isolated from the oral metagenome.Scientific reports · 2019Article
- Conserved collateral antibiotic susceptibility networks in diverse clinical strains of Escherichia coli.Nature communications · 2018Article
- Article
- Article
- Plasmid stability is enhanced by higher-frequency pulses of positive selection.Proceedings. Biological sciences · 2018Article
- Ecology and Evolution of Chromosomal Gene Transfer between Environmental Microorganisms and Pathogens.Microbiology spectrum · 2018Article
- Class 1 integrons are low-cost structures in Escherichia coli.The ISME journal · 2017Article
- Lateral Antimicrobial Resistance Genetic Transfer is active in the open environment.Scientific reports · 2017Article
- Gene Expression in Class 2 Integrons Is SOS-Independent and Involves Two Pc Promoters.Frontiers in microbiology · 2017Article
- Epistasis and the Evolution of Antimicrobial Resistance.Frontiers in microbiology · 2017Review
- The evolutionary dynamics of integrons in changing environments.The ISME journal · 2016Article
- Growth phase-specific evolutionary benefits of natural transformation in Acinetobacter baylyi.The ISME journal · 2015Article
- The genetic basis of the fitness costs of antimicrobial resistance: a meta-analysis approach.Evolutionary applications · 2015Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Horizontal gene transfer (HGT) plays a major role in bacterial microevolution as evident from the rapid emergence and spread of antimicrobial drug resistance. Few studies have however addressed the population dynamics of newly imported genetic elements after HGT. Here, we show that newly acquired class-1 integrons from Salmonella enterica serovar Typhimurium and Acinetobacter baumannii, free of associated transposable elements, strongly reduce host fitness in Acinetobacter baylyi. Insertional inactivation of the integron intI1 restored fitness, demonstrating that the observed fitness costs were due to the presence of an active integrase. The biological cost of harboring class-1 integrons was rapidly reduced during serial transfers due to intI1 frameshift mutations leading to inactivated integrases. We use a mathematical model to explore the conditions where integrons with functional integrases are maintained and conclude that environmental fluctuations and episodic selection is necessary for the maintenance of functional integrases. Taken together, the presented data suggest a trade-off between the ability to capture gene cassettes and long-term stability of integrons and provide an explanation for the frequent observation of inactive integron-integrases in bacterial populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.