ArticlePLoS computational biology2012
Weakly circadian cells improve resynchrony.
Article in PLoS computational biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed.
- Steroid hormone receptors through Cry2 are key players in the circadian clock response to serum.Nature communications · 2025Article
- Article
- The Functional Connectome Mediating Circadian Synchrony in the Suprachiasmatic Nucleus.bioRxiv : the preprint server for biology · 2024Article
- GABAergic signalling in the suprachiasmatic nucleus is required for coherent circadian rhythmicity.The European journal of neuroscience · 2024Article
- A coupled model between circadian, cell-cycle, and redox rhythms reveals their regulation of oxidative stress.Scientific reports · 2024Article
- A minimal model of peripheral clocks reveals differential circadian re-entrainment in aging.Chaos (Woodbury, N.Y.) · 2023Article
- Review
- Review
- Network Structure of the Master Clock Is Important for Its Primary Function.Frontiers in physiology · 2021Review
- Recurring circadian disruption alters circadian clock sensitivity to resetting.The European journal of neuroscience · 2020Article
- Noise-driven cellular heterogeneity in circadian periodicity.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Keeping time in the lamina terminalis: Novel oscillator properties of forebrain sensory circumventricular organs.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Article
- Entrainment of Circadian Rhythms Depends on Firing Rates and Neuropeptide Release of VIP SCN Neurons.Neuron · 2018Article
- Measuring Relative Coupling Strength in Circadian Systems.Journal of biological rhythms · 2018Article
- Resynchronization Dynamics Reveal that the Ventral Entrains the Dorsal Suprachiasmatic Nucleus.Journal of biological rhythms · 2017Article
- Regulating the Suprachiasmatic Nucleus (SCN) Circadian Clockwork: Interplay between Cell-Autonomous and Circuit-Level Mechanisms.Cold Spring Harbor perspectives in biology · 2017Review
- The effects of non-self-sustained oscillators on the en-trainment ability of the suprachiasmatic nucleus.Scientific reports · 2016Article
- The synchronization of neuronal oscillators determined by the directed network structure of the suprachiasmatic nucleus under different photoperiods.Scientific reports · 2016Article
- Inhibitory and excitatory networks balance cell coupling in the suprachiasmatic nucleus: A modeling approach.Journal of theoretical biology · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The mammalian suprachiasmatic nuclei (SCN) contain thousands of neurons capable of generating near 24-h rhythms. When isolated from their network, SCN neurons exhibit a range of oscillatory phenotypes: sustained or damping oscillations, or arrhythmic patterns. The implications of this variability are unknown. Experimentally, we found that cells within SCN explants recover from pharmacologically-induced desynchrony by re-establishing rhythmicity and synchrony in waves, independent of their intrinsic circadian period We therefore hypothesized that a cell's location within the network may also critically determine its resynchronization. To test this, we employed a deterministic, mechanistic model of circadian oscillators where we could independently control cell-intrinsic and network-connectivity parameters. We found that small changes in key parameters produced the full range of oscillatory phenotypes seen in biological cells, including similar distributions of period, amplitude and ability to cycle. The model also predicted that weaker oscillators could adjust their phase more readily than stronger oscillators. Using these model cells we explored potential biological consequences of their number and placement within the network. We found that the population synchronized to a higher degree when weak oscillators were at highly connected nodes within the network. A mathematically independent phase-amplitude model reproduced these findings. Thus, small differences in cell-intrinsic parameters contribute to large changes in the oscillatory ability of a cell, but the location of weak oscillators within the network also critically shapes the degree of synchronization for the population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.