ArticleArchaea (Vancouver, B.C.)2012
Role of Mn2+ and compatible solutes in the radiation resistance of thermophilic bacteria and archaea.
Article in Archaea (Vancouver, B.C.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 74 citations in OpenAlex.
- Biological contributions to manganese oxides in rock varnish at Murujuga (Western Australia).Scientific reports · 2026Article
- Life resists chemistry not conditions.FEMS microbes · 2026Article
- Elucidating the interplay between intracellular manganese-iron-ratio and radiotolerance across all domains of life.FEMS microbes · 2026Article
- Radiotolerant endophytic bacteria and analysis of the effects ofBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- The monomeric archaeal primase from Nanoarchaeum equitans harbours the features of heterodimeric archaeoeukaryotic primases and primes sequence-specifically.Nucleic acids research · 2023Article
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- Genetic Responses of Metabolically ActiveMicroorganisms · 2021Article
- The First Insight into Polyhydroxyalkanoates Accumulation in Multi-ExtremophilicMicroorganisms · 2021Article
- Classes of Drugs that Mitigate Radiation Syndromes.Frontiers in pharmacology · 2021Article
- Effects of Heavy Ion Particle Irradiation on Spore Germination ofLife (Basel, Switzerland) · 2020Article
- The thick waxy coat of mycobacteria, a protective layer against antibiotics and the host's immune system.The Biochemical journal · 2020Review
- Article
- Lack of correlation of desiccation and radiation tolerance in microorganisms from diverse extreme environments tested under anoxic conditions.FEMS microbiology letters · 2018Article
- Gold-chrysophanol nanoparticles suppress human prostate cancer progression through inactivating AKT expression and inducing apoptosis and ROS generation in vitro and in vivo.International journal of oncology · 2017Article
- Microbial radiation-resistance mechanisms.Journal of microbiology (Seoul, Korea) · 2017Review
- Radiation resistance in thermophiles: mechanisms and applications.World journal of microbiology & biotechnology · 2017Review
- Article
- Temporal Gene Expression of the Cyanobacterium Arthrospira in Response to Gamma Rays.PloS one · 2015Article
- Protective effect of trehalose-loaded liposomes against UVB-induced photodamage in human keratinocytes.Biomedical reports · 2014Article
- Challenging the central dogma of skin photobiology: are proteins more important than DNA?The Journal of investigative dermatology · 2014Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Radiation-resistant bacteria have garnered a great deal of attention from scientists seeking to expose the mechanisms underlying their incredible survival abilities. Recent analyses showed that the resistance to ionizing radiation (IR) in the archaeon Halobacterium salinarum is dependent upon Mn-antioxidant complexes responsible for the scavenging of reactive oxygen species (ROS) generated by radiation. Here we examined the role of the compatible solutes trehalose, mannosylglycerate, and di-myo-inositol phosphate in the radiation resistance of aerobic and anaerobic thermophiles. We found that the IR resistance of the thermophilic bacteria Rubrobacter xylanophilus and Rubrobacter radiotolerans was highly correlated to the accumulation of high intracellular concentration of trehalose in association with Mn, supporting the model of Mn(2+)-dependent ROS scavenging in the aerobes. In contrast, the hyperthermophilic archaea Thermococcus gammatolerans and Pyrococcus furiosus did not contain significant amounts of intracellular Mn, and we found no significant antioxidant activity from mannosylglycerate and di-myo-inositol phosphate in vitro. We therefore propose that the low levels of IR-generated ROS under anaerobic conditions combined with highly constitutively expressed detoxification systems in these anaerobes are key to their radiation resistance and circumvent the need for the accumulation of Mn-antioxidant complexes in the cell.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.